PMID- 38407788
OWN - NLM
STAT- Publisher
LR  - 20240226
IS  - 0975-0711 (Electronic)
IS  - 0254-8860 (Linking)
DP  - 2024 Feb 26
TI  - Renal dysfunction in routine proton-pump inhibitor use may be linked to 
      comorbidities: A real-world observational study.
LID - 10.1007/s12664-023-01515-9 [doi]
AB  - INTRODUCTION: The use of proton-pump inhibitors (PPI) is linked with infrequent 
      but serious adverse events, including acute kidney injury, chronic kidney disease 
      (CKD) and progression of CKD. Data on renal safety in routine use of PPI are more 
      relevant to clinical practice. We studied whether such use of PPI is associated 
      with renal dysfunction. METHODS: Patients taking PPI for at least six weeks had 
      serum creatinine tested pre (n = 200) and post (n = 180) recruitment. These 
      patients were then advised to follow-up: those taking PPI for at least 90 days in 
      the next six months (n = 77) and at least another 90 days in the following 
      six months (n = 50), had serum creatinine tested at such follow-up. Renal 
      dysfunction was defined as any increase in serum creatinine level above baseline. 
      RESULTS: The 200 patients recruited had mean age 39.6 (SD 9.2) years. 
      Ninety-eight (49%) patients had a history of previous PPI use (median six months; 
      interquartile range [IQR] 3-24). Only 20 (11.1%) patients at six weeks, 11 
      (14.3%) at six months and six (12%) at one year had increase in creatinine level; 
      a majority of them had less than 0.3 mg/dL increase. Ten of these 20 (six weeks), 
      five of 11 (six months) and five of six (one year) had other risk factors for 
      renal dysfunction. No patient developed CKD during the study period. CONCLUSIONS: 
      Mild and non-progressive increase in serum creatinine occurred in 10% to 15% of 
      patients on routine PPI use. A majority of them had other risk factors. Small 
      sample size and short follow-up duration are a few limitations of this study.
CI  - (c) 2024. Indian Society of Gastroenterology.
FAU - Andhale, Adeshkumar
AU  - Andhale A
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India.
FAU - Abraham, Philip
AU  - Abraham P
AUID- ORCID: 0000-0002-0604-3306
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India. dr_pabraham@hindujahospital.com.
FAU - Dhoble, Pavan
AU  - Dhoble P
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India.
FAU - Desai, Devendra
AU  - Desai D
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India.
FAU - Joshi, Anand
AU  - Joshi A
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India.
FAU - Gupta, Tarun
AU  - Gupta T
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India.
FAU - Kothari, Jatin
AU  - Kothari J
AD  - Division of Nephrology, P D Hinduja Hospital and Medical Research Centre, Mahim, 
      Mumbai, 400 016, India.
FAU - Bhangale, Nikhil
AU  - Bhangale N
AD  - Division of Gastroenterology, P D Hinduja Hospital and Medical Research Centre, 
      Mahim, Mumbai, 400 016, India.
LA  - eng
PT  - Journal Article
DEP - 20240226
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
SB  - IM
OTO - NOTNLM
OT  - Acid suppressant drugs
OT  - Estimated glomerular filtration rate
OT  - Interstitial nephritis
OT  - Renal injury
EDAT- 2024/02/26 12:43
MHDA- 2024/02/26 12:43
CRDT- 2024/02/26 11:52
PHST- 2023/07/24 00:00 [received]
PHST- 2023/12/26 00:00 [accepted]
PHST- 2024/02/26 12:43 [medline]
PHST- 2024/02/26 12:43 [pubmed]
PHST- 2024/02/26 11:52 [entrez]
AID - 10.1007/s12664-023-01515-9 [pii]
AID - 10.1007/s12664-023-01515-9 [doi]
PST - aheadofprint
SO  - Indian J Gastroenterol. 2024 Feb 26. doi: 10.1007/s12664-023-01515-9.