PMID- 38408221
OWN - NLM
STAT- Publisher
LR  - 20240226
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
DP  - 2024 Feb 1
TI  - Morphological Biomarkers Related to Visual Acuity in Patients With Radiation 
      Retinopathy Treated With Intravitreal Ranibizumab.
PG  - 1-8
LID - 10.3928/23258160-20240129-01 [doi]
AB  - BACKGROUND AND OBJECTIVE: Our objective was to monitor variables via 
      spectral-domain optical coherence tomography (SD-OCT) and identify the most 
      relevant biomarkers related to best-corrected visual acuity (BCVA) in radiation 
      retinopathy (RR). PATIENTS AND METHODS: A post-hoc analysis of the two-year 
      Ranibizumab for Radiation Retinopathy (RRR) trial analyzed vision and OCT 
      parameters including intraretinal fluid, ellipsoid zone (EZ) disruption, retinal 
      pigment epithelium atrophy, hard exudates, retinal hemorrhage, retinal 
      neovascularization, and subfoveal fluid. BCVA and SD-OCT parameters were 
      evaluated by univariate analysis and a mixed-effects model. RESULTS: Forty eyes 
      from the RRR trial were included. Intraretinal cyst vertical size (week 24: P = 
      0.032; week 48: P = 0.021), neovascularization (week 48: P = 0.028; week 72: P = 
      0.025), and EZ disruption (week 72: P = 0.029; week 104: P = 0.019) were the 
      clinical parameters most relevant to BCVA by univariate analysis in at least two 
      time points. The mixed-effects model confirmed the relevance of intraretinal cyst 
      vertical size (P = 0.001) and neovascularization (P = 0.001) but not EZ 
      disruption (P = 0.119) over the course of the study. CONCLUSIONS: This study 
      characterizes the course of visual loss in RR by identifying intraretinal cyst 
      vertical size, neovascularization, and EZ disruption as biomarkers of poor BCVA 
      over a span of two years. Larger multicenter studies are needed to confirm these 
      findings. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].
FAU - Corona, Stephanie Trejo
AU  - Corona ST
FAU - Ali, Omar I
AU  - Ali OI
FAU - Yu, Hannah J
AU  - Yu HJ
FAU - Schefler, Amy C
AU  - Schefler AC
CN  - RRR Study Group
LA  - eng
PT  - Journal Article
DEP - 20240201
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
EDAT- 2024/02/26 18:42
MHDA- 2024/02/26 18:42
CRDT- 2024/02/26 15:12
PHST- 2024/02/26 18:42 [medline]
PHST- 2024/02/26 18:42 [pubmed]
PHST- 2024/02/26 15:12 [entrez]
AID - 10.3928/23258160-20240129-01 [doi]
PST - aheadofprint
SO  - Ophthalmic Surg Lasers Imaging Retina. 2024 Feb 1:1-8. doi: 
      10.3928/23258160-20240129-01.