PMID- 38408449
OWN - NLM
STAT- MEDLINE
DCOM- 20240312
LR  - 20240312
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 10
IP  - 3
DP  - 2024 Mar 11
TI  - Construction of a Functional Nucleic Acid-Based Artificial Vesicle-Encapsulated 
      Composite Nanoparticle and Its Application in Retinoblastoma-Targeted 
      Theranostics.
PG  - 1830-1842
LID - 10.1021/acsbiomaterials.3c01972 [doi]
AB  - Retinoblastoma (RB) is an aggressive tumor of the infant retina. However, the 
      ineffective targeting of its theranostic agents results in poor imaging and 
      therapeutic efficacy, which makes it difficult to identify and treat RB at an 
      early stage. In order to improve the imaging and therapeutic efficacy, we 
      constructed an RB-targeted artificial vesicle composite nanoparticle. In this 
      study, the MnO(2) nanosponge (hMNs) was used as the core to absorb two 
      fluorophore-modified DNAzymes to form the Dual/hMNs nanoparticle; after loaded 
      with the artificial vesicle derived from human red blood cells, the RB-targeted 
      DNA aptamers were modified on the surface, thus forming the Apt-EG@Dual/hMNs 
      complex nanoparticle. The DNA aptamer endows this nanoparticle to target the 
      nucleolin-overexpressed RB cell membrane specifically and enters cells via 
      endocytosis. The nanoparticle could release fluorophore-modified DNAzymes and 
      supplies Mn(2+) as a DNAzyme cofactor and a magnetic resonance imaging (MRI) 
      agent. Subsequently, the DNAzymes can target two different mRNAs, thereby 
      realizing fluorescence/MR bimodal imaging and dual-gene therapy. This study is 
      expected to provide a reliable and valuable basis for ocular tumor theranostics.
FAU - Hu, Xueqi
AU  - Hu X
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
FAU - Zhang, Dongdong
AU  - Zhang D
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
FAU - Huang, Linjie
AU  - Huang L
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
FAU - Zeng, Zheng
AU  - Zeng Z
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
FAU - Su, Yina
AU  - Su Y
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
FAU - Chen, Shanshan
AU  - Chen S
AD  - Department of Clinical Laboratory, School of Medical Technology and Engineering, 
      Fujian Medical University, Fuzhou, Fujian 350122, PR China.
FAU - Lin, Xiahui
AU  - Lin X
AUID- ORCID: 0000-0002-1905-1823
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
FAU - Hong, Shanni
AU  - Hong S
AUID- ORCID: 0000-0001-6078-1716
AD  - School of Medical Imaging, Fujian Medical University, Fuzhou, Fujian 350122, PR 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240226
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
RN  - 0 (DNA, Catalytic)
RN  - 0 (Manganese Compounds)
RN  - 0 (Oxides)
SB  - IM
MH  - Humans
MH  - *Retinoblastoma/diagnostic imaging/genetics/therapy
MH  - Precision Medicine
MH  - *DNA, Catalytic
MH  - Manganese Compounds/pharmacology
MH  - Oxides
MH  - *Nanoparticles/therapeutic use
MH  - *Retinal Neoplasms/diagnostic imaging/genetics/therapy
OTO - NOTNLM
OT  - functional nucleic acid
OT  - multifunctional theranostics
OT  - red blood cell membrane-derived artificial vesicle
OT  - retinoblastoma targeting
EDAT- 2024/02/27 00:42
MHDA- 2024/03/12 06:42
CRDT- 2024/02/26 18:33
PHST- 2024/03/12 06:42 [medline]
PHST- 2024/02/27 00:42 [pubmed]
PHST- 2024/02/26 18:33 [entrez]
AID - 10.1021/acsbiomaterials.3c01972 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2024 Mar 11;10(3):1830-1842. doi: 
      10.1021/acsbiomaterials.3c01972. Epub 2024 Feb 26.