PMID- 38408489
OWN - NLM
STAT- Publisher
LR  - 20240226
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
DP  - 2024 Feb 26
TI  - Does the Relationship of the Autonomic Symptoms Questionnaire COMPASS 31 with 
      Cardiovascular Autonomic Tests Differ between Type 1 and Type 2 Diabetes 
      Mellitus?
LID - 10.4093/dmj.2023.0301 [doi]
AB  - BACKGROUND: The aim was to investigate if autonomic symptoms questionnaire 
      Composite Autonomic Symptom Score (COMPASS) 31 has different association with 
      cardiovascular autonomic neuropathy (CAN) and diagnostic performance between type 
      1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). METHODS: 
      Seventy-nine participants with T1DM and 140 with T2DM completed COMPASS 31 before 
      cardiovascular reflex tests (CARTs) for CAN, and assessment of symptoms, signs, 
      vibration, and thermal perception thresholds for diabetic polyneuropathy (DPN) 
      diagnosis. RESULTS: COMPASS 31 total weighted score (TWS) was similar in the two 
      groups, but significantly associated with confirmed CAN only in T1DM (P=0.0056) 
      and not T2DM group (P=0.1768) and correlated with CARTs score more strongly in 
      T1DM (rho=0.356, P=0.0016) than in T2DM group (rho=0.084, P=0.3218) (P=0.016). 
      Only in T1DM and not T2DM group, the area under the receiver operating 
      characteristic curve (AUC) reached a fair diagnostic accuracy (>0.7) for 
      confirmed CAN (0.73+/-0.07 vs. 0.61+/-0.08) and DPN (0.75+/-0.06 vs. 0.68+/-0.05), 
      although without a significant difference. COMPASS 31 TWS (cut-off 16.44) reached 
      acceptable diagnostic performance in T1DM, with sensitivity for confirmed CAN 
      81.2% and sensitivity and specificity for DPN 76.3% and 78%, compared to T2DM 
      group (all <70%). AUC for DPN of orthostatic intolerance domain was higher in 
      T1DM compared to T2DM group (0.73+/-0.05 vs. 0.58+/-0.04, P=0.027). CONCLUSION: 
      COMPASS 31 is more weakly related to CAN in T2DM than in T1DM, with a fair 
      diagnostic accuracy for confirmed CAN only in T1DM. This difference supports a 
      multifactorial origin of symptoms and should be considered when using COMPASS 31.
FAU - D'Ippolito, Ilenia
AU  - D'Ippolito I
AD  - Endocrinology Section, Department of Systems Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Menduni, Marika
AU  - Menduni M
AD  - Endocrinology Section, Department of Systems Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - D'Amato, Cinzia
AU  - D'Amato C
AD  - Endocrinology Section, Department of Systems Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Andreadi, Aikaterini
AU  - Andreadi A
AD  - Endocrinology Section, Department of Systems Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Lauro, Davide
AU  - Lauro D
AD  - Endocrinology Section, Department of Systems Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Spallone, Vincenza
AU  - Spallone V
AD  - Endocrinology Section, Department of Systems Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240226
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
OTO - NOTNLM
OT  - Autonomic nervous system diseases
OT  - Diabetes mellitus, type 1
OT  - Diabetes mellitus, type 2
OT  - Diabetic neuropathies
OT  - Diagnosis
OT  - Neurologic manifestations
OT  - Orthostatic intolerance
EDAT- 2024/02/27 00:42
MHDA- 2024/02/27 00:42
CRDT- 2024/02/26 19:11
PHST- 2023/08/28 00:00 [received]
PHST- 2023/11/22 00:00 [accepted]
PHST- 2024/02/27 00:42 [medline]
PHST- 2024/02/27 00:42 [pubmed]
PHST- 2024/02/26 19:11 [entrez]
AID - dmj.2023.0301 [pii]
AID - 10.4093/dmj.2023.0301 [doi]
PST - aheadofprint
SO  - Diabetes Metab J. 2024 Feb 26. doi: 10.4093/dmj.2023.0301.