PMID- 38408707
OWN - NLM
STAT- MEDLINE
DCOM- 20240318
LR  - 20240318
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 224
DP  - 2024 Apr
TI  - Radiological and histopathological features and treatment response by subtypes of 
      interstitial pneumonia with autoimmune features: A prospective, multicentre 
      cohort study.
PG  - 107577
LID - S0954-6111(24)00051-9 [pii]
LID - 10.1016/j.rmed.2024.107577 [doi]
AB  - BACKGROUND: Patients with idiopathic interstitial pneumonia (IIP) have a 
      favourable prognosis when they have interstitial pneumonia with autoimmune 
      features (IPAF). However, precise IPAF-related findings from high-resolution 
      computed tomography (HRCT) and lung histopathological specimens and the treatment 
      response have not been fully determined. Therefore, this study was conducted to 
      evaluate the relationship between findings on HRCT or lung histopathological 
      specimens and the progression of interstitial pneumonia in patients with IPAF. 
      METHODS: This multicentre cohort study prospectively enrolled consecutive 
      patients with IIP. At the diagnosis of IIP, we systematically evaluated 74 
      features suggestive of connective tissue diseases and followed them up. HRCT, 
      lung specimens, serum antibodies, and the clinical course were also evaluated. 
      RESULTS: Among 222 patients with IIP, 26 (11.7%) fulfilled the IPAF criteria. 
      During a median observation period of 36 months, patients with IPAF showed better 
      survival than those without IPAF (p = 0.034). While histopathological findings 
      were not related to IPAF, nonspecific interstitial pneumonia (NSIP) with 
      organizing pneumonia (OP) overlap was the most prevalent HRCT pattern (p < 0.001) 
      and the consolidation opacity was the most common radiological finding in IPAF 
      (p = 0.017). Furthermore, in patients with IPAF, the diagnosis of COP or NSIP 
      with OP overlap was associated with a higher increase in %FVC in 1 year than in 
      those with idiopathic pulmonary fibrosis, NSIP, or unclassifiable IIP 
      (p = 0.002). CONCLUSIONS: This study shows the presence of consolidation opacity 
      on HRCT and the diagnosis of COP or NSIP with OP overlap are associated with IPAF 
      and its favourable treatment response in patients with IPAF.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Enomoto, Noriyuki
AU  - Enomoto N
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan; Health Administration Center, Hamamatsu University 
      School of Medicine, Hamamatsu, Japan. Electronic address: norieno@hama-med.ac.jp.
FAU - Yazawa, Shusuke
AU  - Yazawa S
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Mochizuka, Yasutaka
AU  - Mochizuka Y
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Fukada, Atsuki
AU  - Fukada A
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Tanaka, Yuko
AU  - Tanaka Y
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Naoi, Hyogo
AU  - Naoi H
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Aono, Yuya
AU  - Aono Y
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan; Department of Respiratory Medicine, Seirei Hamamatsu 
      General Hospital, Hamamatsu, Japan.
FAU - Inoue, Yusuke
AU  - Inoue Y
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Yasui, Hideki
AU  - Yasui H
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Karayama, Masato
AU  - Karayama M
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Suzuki, Yuzo
AU  - Suzuki Y
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Hozumi, Hironao
AU  - Hozumi H
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Furuhashi, Kazuki
AU  - Furuhashi K
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Toyoshima, Mikio
AU  - Toyoshima M
AD  - Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Hamamatsu, Japan.
FAU - Kono, Masato
AU  - Kono M
AD  - Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, 
      Japan.
FAU - Imokawa, Shiro
AU  - Imokawa S
AD  - Department of Respiratory Medicine, Iwata City Hospital, Iwata, Japan.
FAU - Sano, Takehisa
AU  - Sano T
AD  - Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, 
      Japan.
FAU - Akamatsu, Taisuke
AU  - Akamatsu T
AD  - Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
FAU - Koshimizu, Naoki
AU  - Koshimizu N
AD  - Department of Respiratory Medicine, Fujieda Municipal General Hospital, Fujieda, 
      Japan.
FAU - Yokomura, Koshi
AU  - Yokomura K
AD  - Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara 
      General Hospital, Hamamatsu, Japan.
FAU - Matsuda, Hiroyuki
AU  - Matsuda H
AD  - Department of Respiratory Medicine, Japanese Red Cross Shizuoka Hospital, 
      Shizuoka, Japan.
FAU - Kaida, Yusuke
AU  - Kaida Y
AD  - Department of Respiratory Medicine, Enshu Hospital, Hamamatsu, Japan.
FAU - Shirai, Masahiro
AU  - Shirai M
AD  - Respiratory and Allergy Medicine, National Hospital Organization Tenryu Hospital, 
      Hamamatsu, Japan.
FAU - Mori, Kazutaka
AU  - Mori K
AD  - Respiratory Medicine, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
FAU - Masuda, Masafumi
AU  - Masuda M
AD  - Respiratory Medicine, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
FAU - Fujisawa, Tomoyuki
AU  - Fujisawa T
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Inui, Naoki
AU  - Inui N
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan; Department of Clinical Pharmacology and Therapeutics, 
      Hamamatsu University School of Medicine, Hamamatsu, Japan.
FAU - Nakamura, Yutaro
AU  - Nakamura Y
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan; Respiratory and Allergy Medicine, National Hospital 
      Organization Tenryu Hospital, Hamamatsu, Japan.
FAU - Sugiura, Hiroaki
AU  - Sugiura H
AD  - Department of Radiology, National Defense Medical College, Saitama, Japan.
FAU - Sumikawa, Hiromitsu
AU  - Sumikawa H
AD  - Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical 
      Center, Osaka, Japan.
FAU - Kitani, Masashi
AU  - Kitani M
AD  - Department of Pathology, National Hospital Organization Tokyo National Hospital, 
      Tokyo, Japan.
FAU - Tabata, Kazuhiro
AU  - Tabata K
AD  - Department of Pathology, Kagoshima University Graduate School of Medical and 
      Dental Sciences, Kagoshima, Japan.
FAU - Ogawa, Noriyoshi
AU  - Ogawa N
AD  - Division of Immunology and Rheumatology, Department of Internal Medicine 3, 
      Hamamatsu University School of Medicine, Hamamatsu, Japan.
FAU - Suda, Takafumi
AU  - Suda T
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20240224
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Humans
MH  - Cohort Studies
MH  - Prospective Studies
MH  - *Autoimmune Diseases/complications/diagnostic imaging
MH  - Retrospective Studies
MH  - *Lung Diseases, Interstitial/diagnosis
MH  - *Idiopathic Interstitial Pneumonias/diagnosis
MH  - *Connective Tissue Diseases/complications/diagnostic imaging
OTO - NOTNLM
OT  - Anti-aminoacyl tRNA synthetase (ARS) antibody
OT  - Idiopathic interstitial pneumonia
OT  - Interstitial pneumonia with autoimmune features
OT  - Nonspecific interstitial pneumonia
OT  - Organizing pneumonia
COIS- Declaration of competing interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Noriyuki Enomoto received funding from Boehringer Ingelheim Japan Co., 
      Ltd. All of other authors did not receive funding.
EDAT- 2024/02/27 00:42
MHDA- 2024/03/18 06:42
CRDT- 2024/02/26 19:18
PHST- 2023/12/30 00:00 [received]
PHST- 2024/02/07 00:00 [revised]
PHST- 2024/02/20 00:00 [accepted]
PHST- 2024/03/18 06:42 [medline]
PHST- 2024/02/27 00:42 [pubmed]
PHST- 2024/02/26 19:18 [entrez]
AID - S0954-6111(24)00051-9 [pii]
AID - 10.1016/j.rmed.2024.107577 [doi]
PST - ppublish
SO  - Respir Med. 2024 Apr;224:107577. doi: 10.1016/j.rmed.2024.107577. Epub 2024 Feb 
      24.