PMID- 38410303
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240229
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Jan
TI  - Evaluating the Diagnostic Potential of Serum Vascular Endothelial Growth Factor 
      and Adiponectin in Diabetic Peripheral Neuropathy.
PG  - e53017
LID - 10.7759/cureus.53017 [doi]
LID - e53017
AB  - INTRODUCTION: Diabetic peripheral neuropathy (DPN) presents a formidable health 
      challenge in type 2 diabetes mellitus (T2DM) patients. This study in eastern 
      Uttar Pradesh aims to assess the roles of vascular endothelial growth factor 
      (VEGF) and adiponectin in DPN, recognizing the crucial need for understanding its 
      molecular underpinnings for enhanced diagnosis and management. METHODS: In a 
      cross-sectional study analyzing clinical and biochemical data, 86 individuals 
      aged 35 to 65 years were examined, including 43 with neuropathy and 43 without. 
      Neuropathy assessment included the neuropathy symptom score (NSS), diabetes 
      neuropathy examination (DNE) score, and nerve conduction studies. Levels of VEGF 
      and adiponectin were correlated with motor nerve amplitude, NSS, and DNE scores. 
      Receiver operating characteristic (ROC) curve analysis gauged diagnostic 
      potential, and logistic regression assessed predictors for DPN. RESULTS: Patients 
      with neuropathy exhibited significantly elevated VEGF levels compared to those 
      without, while adiponectin showed no significant difference. VEGF demonstrated a 
      negative correlation with motor nerve amplitude and a positive correlation with 
      NSS and DNE scores. ROC analysis revealed strong diagnostic capability for VEGF 
      (area under the curve: 0.807). NSS and DNE scores indicated good and moderate 
      diagnostic accuracy, respectively. In logistic regression analysis, VEGF emerged 
      as the sole significant predictor (odds ratio: 1.11, 95% CI (1.03, 1.20), p = 
      0.0092). CONCLUSION: Findings suggest VEGF's potential as a biomarker for 
      diagnosing DPN in T2DM, associated with neuropathy severity. Adiponectin showed 
      no significant association. The study underscores NSS and DNE scores' therapeutic 
      relevance as valid neuropathy assessment tools.
CI  - Copyright (c) 2024, Mohanraj et al.
FAU - Mohanraj, Palani Selvam
AU  - Mohanraj PS
AD  - Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
FAU - Das, Arani
AU  - Das A
AD  - Physiology, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
FAU - Sen, Aniruddha
AU  - Sen A
AD  - Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
FAU - Ranjan, Amit
AU  - Ranjan A
AD  - Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, 
      Gorakhpur, Gorakhpur, IND.
FAU - Rajendran, Vinoth
AU  - Rajendran V
AD  - Community Medicine and Family Medicine, All India Institute of Medical Sciences, 
      Gorakhpur, Gorakhpur, IND.
FAU - Velu, Anupriya
AU  - Velu A
AD  - Biochemistry, Mahayogi Gorakhnath University Gorakhpur, Gorakhpur, IND.
FAU - Venkatesh, U
AU  - Venkatesh U
AD  - Community Medicine and Family Medicine, All India Institute of Medical Sciences, 
      Gorakhpur, Gorakhpur, IND.
LA  - eng
PT  - Journal Article
DEP - 20240126
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10895556
OTO - NOTNLM
OT  - adiponectin
OT  - biomarkers
OT  - diabetes neuropathy examination score
OT  - diabetic peripheral neuropathy
OT  - neuropathy symptom score
OT  - vascular endothelial growth factor
OT  - vegf
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/02/27 06:44
MHDA- 2024/02/27 06:45
PMCR- 2024/01/26
CRDT- 2024/02/27 03:37
PHST- 2024/01/26 00:00 [accepted]
PHST- 2024/02/27 06:45 [medline]
PHST- 2024/02/27 06:44 [pubmed]
PHST- 2024/02/27 03:37 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - 10.7759/cureus.53017 [doi]
PST - epublish
SO  - Cureus. 2024 Jan 26;16(1):e53017. doi: 10.7759/cureus.53017. eCollection 2024 
      Jan.