PMID- 38410697
OWN - NLM
STAT- MEDLINE
DCOM- 20240228
LR  - 20240307
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 15
DP  - 2024
TI  - Non-linear associations of cardiometabolic index with insulin resistance, 
      impaired fasting glucose, and type 2 diabetes among US adults: a cross-sectional 
      study.
PG  - 1341828
LID - 10.3389/fendo.2024.1341828 [doi]
LID - 1341828
AB  - BACKGROUND: Cardiometabolic index (CMI) is a novel indicator for predicting the 
      risk of obesity-related diseases. We aimed to determine the relationships of CMI 
      with insulin resistance (IR), impaired fasting glucose (IFG), and type 2 diabetes 
      mellitus (T2DM) using NHANES data from 1999 to 2020. METHODS: After CMI values 
      were estimated, weighted univariate and multivariate logistic regression analyses 
      were used to ascertain whether CMI was an independent risk indicator for IR, IFG, 
      and T2DM. Furthermore, stratified analyses and interaction analyses were carried 
      out to investigate the heterogeneity of correlations across various subgroups. 
      Subsequently, restricted cubic splines (RCS) were used to examine nonlinear 
      relationships. RESULTS: 21,304 US adults were enrolled in our study, of whom 
      5,326 (22.38%) had IR, 4,706 (20.17%) had IFG, and 3,724 (13.02%) had T2DM. In 
      the studied population, a higher CMI index value was significantly associated 
      with an elevated likelihood of IR, IFG, and T2DM. In the RCS regression model, 
      the relationship between CMI and IR, IFG, and T2DM was identified as nonlinear. A 
      nonlinear inverted U-shaped relationship was found between CMI and IFG, and an 
      inverse L-shaped association was observed between CMI and IR, CMI and T2DM. The 
      cut-off values of CMI were 1.35, 1.48, and 1.30 for IR, IFG, and T2DM, 
      respectively. CONCLUSION: Our results indicate that CMI was positively correlated 
      with an increase in IR, IFG, and T2DM in the studied population. CMI may be a 
      simple and effective surrogate indicator of IR, IFG, and T2DM.
CI  - Copyright (c) 2024 Song, Li, Zhu, Liang, Xue and Zhu.
FAU - Song, Jimei
AU  - Song J
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Li, Yimei
AU  - Li Y
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Zhu, Junxia
AU  - Zhu J
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Liang, Jian
AU  - Liang J
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Xue, Shan
AU  - Xue S
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Zhu, Zhangzhi
AU  - Zhu Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240212
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Insulin Resistance
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - Blood Glucose
MH  - Fasting
MH  - *Prediabetic State
MH  - Risk Factors
MH  - *Cardiovascular Diseases
PMC - PMC10894973
OTO - NOTNLM
OT  - NHANES
OT  - cardiometabolic index
OT  - impaired fasting glucose
OT  - insulin resistance
OT  - population-based study
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/27 06:44
MHDA- 2024/02/28 06:45
PMCR- 2024/01/01
CRDT- 2024/02/27 03:43
PHST- 2023/11/21 00:00 [received]
PHST- 2024/01/25 00:00 [accepted]
PHST- 2024/02/28 06:45 [medline]
PHST- 2024/02/27 06:44 [pubmed]
PHST- 2024/02/27 03:43 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2024.1341828 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2024 Feb 12;15:1341828. doi: 
      10.3389/fendo.2024.1341828. eCollection 2024.