PMID- 38411670
OWN - NLM
STAT- MEDLINE
DCOM- 20240319
LR  - 20240319
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 97
IP  - 3
DP  - 2024 Apr
TI  - Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma 
      in adolescents.
PG  - 331-339
LID - 10.1007/s00420-024-02047-1 [doi]
AB  - BACKGROUND: Previous epidemiological studies about the relationship between per- 
      and polyfluoroalkyl substances (PFAS) concentrations and adolescent asthma have 
      typically examined single PFAS, without considering the mixtures effects of PFAS. 
      METHODS: Using data from the 2013-2018 National Health and Nutrition Examination 
      Survey (NHANES), 886 adolescents aged 12-19 years were included in this study. We 
      explored the association between PFAS mixture concentrations and adolescent 
      asthma using weighted quantile sum (WQS) regression and Bayesian kernel machine 
      regression (BKMR) models, respectively. RESULTS: After adjusting for confounders, 
      the results of the WQS regression and BKMR models were consistent, with mixed 
      exposure to the five PFAS not significantly associated with asthma in all 
      adolescents. The association remained nonsignificant in the subgroup analysis by 
      sex. CONCLUSIONS: Our study demonstrated no significant association between mixed 
      exposure to PFAS and adolescent asthma, and more large cohort studies are needed 
      to confirm this in the future.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wang, Yi-Fan
AU  - Wang YF
AUID- ORCID: 0000-0002-5946-1798
AD  - Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.
AD  - Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of 
      Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 
      300074, China.
FAU - Li, Li
AU  - Li L
AD  - Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.
AD  - Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of 
      Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 
      300074, China.
FAU - Wang, Xu
AU  - Wang X
AD  - Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.
AD  - Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of 
      Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 
      300074, China.
FAU - Yun, Ya-Nan
AU  - Yun YN
AD  - Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of 
      Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 
      300074, China.
FAU - Wang, Xue-Lin
AU  - Wang XL
AD  - Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of 
      Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 
      300074, China.
FAU - He, En-Yang
AU  - He EY
AD  - Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.
FAU - Song, Ming-Kun
AU  - Song MK
AD  - Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping 
      District, Tianjin, 300070, China.
FAU - Xia, Xue-Hong
AU  - Xia XH
AD  - Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.
FAU - Zou, Ying-Xue
AU  - Zou YX
AD  - Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of 
      Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 
      300074, China. tmuzouyingxue@163.com.
LA  - eng
GR  - TJYXZDXK-040A/Tianjin Children's Hospital/
PT  - Journal Article
DEP - 20240227
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - Bayes Theorem
MH  - Nutrition Surveys
MH  - Environmental Exposure/adverse effects
MH  - *Asthma/epidemiology
MH  - *Fluorocarbons
OTO - NOTNLM
OT  - Adolescents
OT  - Asthma
OT  - Mixture effects
OT  - Per- and polyfluoroalkyl substances
EDAT- 2024/02/27 12:47
MHDA- 2024/03/19 06:43
CRDT- 2024/02/27 11:05
PHST- 2023/11/17 00:00 [received]
PHST- 2024/01/16 00:00 [accepted]
PHST- 2024/03/19 06:43 [medline]
PHST- 2024/02/27 12:47 [pubmed]
PHST- 2024/02/27 11:05 [entrez]
AID - 10.1007/s00420-024-02047-1 [pii]
AID - 10.1007/s00420-024-02047-1 [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2024 Apr;97(3):331-339. doi: 
      10.1007/s00420-024-02047-1. Epub 2024 Feb 27.