PMID- 38414271
OWN - NLM
STAT- Publisher
LR  - 20240228
IS  - 1943-4936 (Electronic)
IS  - 1040-6387 (Linking)
DP  - 2024 Feb 27
TI  - Retrospective analysis of antimicrobial resistance in bacterial pathogens from 
      pet rabbits in Hong Kong, 2019-2022.
PG  - 10406387241233546
LID - 10.1177/10406387241233546 [doi]
AB  - Antimicrobial resistance (AMR) is a growing threat to human and animal health. 
      Data are limited on the prevalence of resistant bacteria in pet rabbits. 
      Therefore, we aimed to identify prevalent bacterial infections and AMR profiles 
      among pet rabbits in Hong Kong (HK). Our search of the CityU Veterinary 
      Diagnostic Laboratory (VDL) database found 301 cases of pet rabbits submitted for 
      bacteriologic and antimicrobial susceptibility testing by veterinarians at 20 
      exotic veterinary clinics across HK between 2019 and 2022. The rabbits were of 8 
      different breeds and had a median age of 6.5 y, with 54.8% males, 40.2% females, 
      and 5% unspecified. Of the 301 samples received, 168 (55.8%) had positive 
      bacterial growth; 125 (74.4%) had single bacterial isolates, and 43 (25.6%) had 
      mixed cultures. Cultures included Enterococcus faecalis (21.3%) as the most 
      frequently isolated gram-positive bacterium, followed by Streptococcus 
      intermedius (12.5%), and Staphylococcus aureus (11.3%). The most frequently 
      isolated gram-negative bacteria were Pseudomonas aeruginosa (18.1%), followed by 
      Escherichia coli (8.3%), Pasteurella multocida (6.9%), and Klebsiella pneumoniae 
      (4.2%). Approximately 83% of the isolates had acquired resistance to at least one 
      antimicrobial agent, and 49.4% were multidrug-resistant. The isolated bacteria 
      had high levels of resistance to penicillin (69.8%), clindamycin (47.4%), and 
      doxycycline (46.9%). Our findings highlight the high levels of AMR in bacteria 
      isolated from pet rabbit clinical samples in HK; many of these bacteria are 
      zoonotic and pose a public health threat.
FAU - Xin, Chen
AU  - Xin C
AD  - Department of Infectious Diseases and Public Health, Jockey Club College of 
      Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 
      SAR, China.
FAU - Hill, Fraser
AU  - Hill F
AUID- ORCID: 0000-0002-0338-1895
AD  - CityU Veterinary Diagnostic Laboratory, City University of Hong Kong, Hong Kong 
      SAR, China.
FAU - Elsohaby, Ibrahim
AU  - Elsohaby I
AUID- ORCID: 0000-0003-2533-988X
AD  - Department of Infectious Diseases and Public Health, Jockey Club College of 
      Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 
      SAR, China.
AD  - Centre for Applied One Health Research and Policy Advice (OHRP), City University 
      of Hong Kong, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
DEP - 20240227
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
OTO - NOTNLM
OT  - Hong Kong
OT  - antimicrobial resistance
OT  - bacterial pathogens
OT  - clinical samples
OT  - rabbits
COIS- Declaration of conflicting interestThe authors declared no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/02/28 06:43
MHDA- 2024/02/28 06:43
CRDT- 2024/02/28 02:45
PHST- 2024/02/28 06:43 [medline]
PHST- 2024/02/28 06:43 [pubmed]
PHST- 2024/02/28 02:45 [entrez]
AID - 10.1177/10406387241233546 [doi]
PST - aheadofprint
SO  - J Vet Diagn Invest. 2024 Feb 27:10406387241233546. doi: 
      10.1177/10406387241233546.