PMID- 38414613
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240229
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 12
IP  - 5
DP  - 2024 Feb 16
TI  - Value of glucose transport protein 1 expression in detecting lymph node 
      metastasis in patients with colorectal cancer.
PG  - 931-941
LID - 10.12998/wjcc.v12.i5.931 [doi]
AB  - BACKGROUND: There are limited data on the use of glucose transport protein 1 
      (GLUT-1) expression as a biomarker for predicting lymph node metastasis in 
      patients with colorectal cancer. GLUT-1 and GLUT-3, hexokinase (HK)-II, and 
      hypoxia-induced factor (HIF)-1 expressions may be useful biomarkers for detecting 
      primary tumors and lymph node metastasis when combined with fluorodeoxyglucose 
      (FDG) uptake on positron emission tomography/computed tomography (PET/CT). AIM: 
      To evaluate GLUT-1, GLUT-3, HK-II, and HIF-1 expressions as biomarkers for 
      detecting primary tumors and lymph node metastasis with 18F-FDG-PET/CT. METHODS: 
      This retrospective study included 169 patients with colorectal cancer who 
      underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National 
      University Hospital between January 2009 and May 2012. Two tissue cores from the 
      central and peripheral areas of the tumors were obtained and were examined by a 
      dedicated pathologist, and the expressions of GLUT-1, GLUT-3, HK-II, and HIF-1 
      were determined using immunohistochemical staining. We analyzed the correlations 
      among their expressions, various clinicopathological factors, and the maximum 
      standardized uptake value (SUVmax) of PET/CT. RESULTS: GLUT-1 was found at the 
      center or periphery of the tumors in 109 (64.5%) of the 169 patients. GLUT-1 
      positivity was significantly correlated with the SUVmax of the primary tumor and 
      lymph nodes, regardless of the biopsy site (tumor center, P < 0.001 and P = 
      0.012; tumor periphery, P = 0.030 and P = 0.010, respectively). GLUT-1 positivity 
      and negativity were associated with higher and lower sensitivities of PET/CT, 
      respectively, for the detection of lymph node metastasis, regardless of the 
      biopsy site. GLUT3, HK-II, and HIF-1 expressions were not significantly 
      correlated with the SUVmax of the primary tumor and lymph nodes. CONCLUSION: 
      GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT 
      for primary tumors and lymph nodes. Clinicians should consider GLUT-1 expression 
      in preoperative endoscopic biopsy in interpreting PET/CT findings.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Kim, Hongsik
AU  - Kim H
AD  - Department of Internal Medicine, Chungbuk National University Hospital, Cheongju 
      28644, South Korea.
FAU - Choi, Song-Yi
AU  - Choi SY
AD  - Department of Pathology, Chungnam National University College of Medicine, 
      Daejeon 35015, South Korea.
FAU - Heo, Tae-Young
AU  - Heo TY
AD  - Information and Statistics, Chungbuk National University, Cheongju 28644, South 
      Korea.
FAU - Kim, Kyeong-Rok
AU  - Kim KR
AD  - Information and Statistics, Chungbuk National University, Cheongju 28644, South 
      Korea.
FAU - Lee, Jisun
AU  - Lee J
AD  - Department of Radiology, College of Medicine, Chungbuk National University, 
      Chungbuk National University Hospital, Cheongju-si 28644, South Korea.
FAU - Yoo, Min Young
AU  - Yoo MY
AD  - Department of Nuclear Medicine, School of Medicine, Inha University, Incheon 
      22332, South Korea.
FAU - Lee, Taek-Gu
AU  - Lee TG
AD  - Department of Surgery, Chungbuk National University, College of Medicine, 
      Cheongju-si 28644, South Korea.
FAU - Han, Joung-Ho
AU  - Han JH
AD  - Department of Internal Medicen, Chungbuk National University, College of 
      medicine, Cheongju-si 28644, South Korea. joungho@chungbuk.ac.kr.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC10895641
OTO - NOTNLM
OT  - 18F-FDG-PET-CT
OT  - Biomarker
OT  - Colorectal neoplasms
OT  - Glucose transporter type 1
OT  - Lymph node
COIS- Conflict-of-interest statement: The authors have no conflict of interest to 
      declare regarding the publication of this work.
EDAT- 2024/02/28 06:45
MHDA- 2024/02/28 06:46
PMCR- 2024/02/16
CRDT- 2024/02/28 03:47
PHST- 2023/11/09 00:00 [received]
PHST- 2024/01/04 00:00 [revised]
PHST- 2024/01/22 00:00 [accepted]
PHST- 2024/02/28 06:46 [medline]
PHST- 2024/02/28 06:45 [pubmed]
PHST- 2024/02/28 03:47 [entrez]
PHST- 2024/02/16 00:00 [pmc-release]
AID - 10.12998/wjcc.v12.i5.931 [doi]
PST - ppublish
SO  - World J Clin Cases. 2024 Feb 16;12(5):931-941. doi: 10.12998/wjcc.v12.i5.931.