PMID- 38417344
OWN - NLM
STAT- MEDLINE
DCOM- 20240313
LR  - 20240313
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 704
DP  - 2024 Apr 16
TI  - Synthesis of urolithin derivatives and their anti-inflammatory activity.
PG  - 149711
LID - S0006-291X(24)00247-X [pii]
LID - 10.1016/j.bbrc.2024.149711 [doi]
AB  - Two series of urolithin derivatives, totally 38 compounds, were synthesized. 
      Their anti-inflammatory activity was investigated by detecting the inhibitory 
      effects on the expression of TNF-alpha in bone marrow-derived macrophages (BMDMs), 
      showing that 24 of 38 ones reduced the expression of TNF-alpha. Compound B2, the ring 
      C opened derivative of urolithin B with a butoxycarbonyl substitution in ring A, 
      showed the strongest inhibitory activity compared with that of indomethacin. 
      Furthermore, B2 treatment decreased the expression of pro-inflammatory factors 
      IL-1beta, IL-6, iNOS and COX-2. Mechanically, the anti-inflammatory effect of B2 was 
      related to the inhibition of NF-kappaB signaling pathway. These results clearly 
      illustrated that B2 hold potential for application as an anti-inflammatory agent. 
      The present study provided a viable approach to modify the gut metabolites for 
      anti-inflammatory drug development.
CI  - Copyright (c) 2024 Elsevier Inc. All rights reserved.
FAU - Li, Xintong
AU  - Li X
AD  - Key Laboratory of Chemical Biology (Ministry of Education), School of 
      Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 
      Shandong, 250012, China.
FAU - Zhang, Zhengzheng
AU  - Zhang Z
AD  - Key Laboratory of Chemical Biology (Ministry of Education), School of 
      Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 
      Shandong, 250012, China.
FAU - Xu, Guangsen
AU  - Xu G
AD  - Key Laboratory of Chemical Biology (Ministry of Education), School of 
      Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 
      Shandong, 250012, China.
FAU - Li, Zhiying
AU  - Li Z
AD  - Key Laboratory of Chemical Biology (Ministry of Education), School of 
      Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 
      Shandong, 250012, China.
FAU - Lu, Chunhua
AU  - Lu C
AD  - Key Laboratory of Chemical Biology (Ministry of Education), School of 
      Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 
      Shandong, 250012, China. Electronic address: ahua0966@sdu.edu.cn.
FAU - Shen, Yuemao
AU  - Shen Y
AD  - Key Laboratory of Chemical Biology (Ministry of Education), School of 
      Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 
      Shandong, 250012, China. Electronic address: yshen@sdu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240223
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (NF-kappa B)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Humans
MH  - *Tumor Necrosis Factor-alpha/metabolism
MH  - *Inflammation/drug therapy
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Signal Transduction
MH  - NF-kappa B/metabolism
MH  - Lipopolysaccharides/pharmacology/therapeutic use
OTO - NOTNLM
OT  - Anti-inflammation activity
OT  - NF-kappaB
OT  - Structure-activity relationship
OT  - Urolithin
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/29 00:43
MHDA- 2024/03/13 06:47
CRDT- 2024/02/28 18:08
PHST- 2023/12/09 00:00 [received]
PHST- 2024/02/13 00:00 [revised]
PHST- 2024/02/21 00:00 [accepted]
PHST- 2024/03/13 06:47 [medline]
PHST- 2024/02/29 00:43 [pubmed]
PHST- 2024/02/28 18:08 [entrez]
AID - S0006-291X(24)00247-X [pii]
AID - 10.1016/j.bbrc.2024.149711 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2024 Apr 16;704:149711. doi: 
      10.1016/j.bbrc.2024.149711. Epub 2024 Feb 23.