PMID- 38418651
OWN - NLM
STAT- MEDLINE
DCOM- 20240301
LR  - 20240302
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 29
TI  - Long-term monitoring of gastric mucosa-associated lymphoid tissue lymphoma in 
      patients with extra copies of the MALT1 gene.
PG  - 4953
LID - 10.1038/s41598-024-55663-9 [doi]
LID - 4953
AB  - The objective of this study was to clarify the long-term prognosis of patients 
      with gastric mucosa-associated lymphoid tissue (MALT) lymphoma with additional 
      copies of MALT1. In this multicenter retrospective study, we enrolled 145 
      patients with gastric MALT lymphoma who underwent fluorescence in situ 
      hybridization (FISH) analysis to detect t(11;18) translocation. The patient 
      cohort was divided into three groups: Group A (n = 87), comprising individuals 
      devoid of the t(11;18) translocation or extra MALT1 copies; Group B (n = 27), 
      encompassing patients characterized by the presence of the t(11;18) 
      translocation; and Group C (n = 31), including patients with extra MALT1 copies. 
      The clinical outcomes in each cohort were collected. Over the course of a mean 
      follow-up of 8.5 +/- 4.2 years, one patient died of progressive MALT lymphoma, 
      while 15 patients died due to etiologies unrelated to lymphoma. The progression 
      or relapse of MALT lymphoma was observed in 11 patients: three in Group A, two in 
      Group B, and six in Group C. In Groups A, B, and C, the 10-year overall survival 
      rates were 82.5%, 93.8%, and 86.4%, respectively, and the 10-year event-free 
      survival rates were 96.1%, 96.0%, and 82.9%, respectively. The event-free 
      survival rate in Group C was significantly lower than that in Group A. However, 
      no differences were observed in the 10-year event-free survival rates among 
      individuals limited to stage I or II(1) disease (equivalent to excluding patients 
      with stage IV disease in this study, as there were no patients with stage II(2)), 
      with rates of 98.6%, 95.8%, and 92.3% for Groups A, B, and C, respectively. In 
      conclusion, the presence of extra copies of MALT1 was identified as an inferior 
      prognostic determinant of event-free survival. Consequently, trisomy/tetrasomy 18 
      may serve as an indicator of progression and refractoriness to therapeutic 
      intervention in patients with gastric MALT lymphoma, particularly stage IV 
      gastric MALT lymphoma.
CI  - (c) 2024. The Author(s).
FAU - Iwamuro, Masaya
AU  - Iwamuro M
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School 
      of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, 
      Okayama, 700-8558, Japan. pr145h2k@okayama-u.ac.jp.
FAU - Takenaka, Ryuta
AU  - Takenaka R
AD  - Department of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, 708‑0841, Japan.
FAU - Miyahara, Koji
AU  - Miyahara K
AD  - Department of Internal Medicine, Hiroshima City Hospital, Hiroshima, 730-8518, 
      Japan.
FAU - Okanoue, Shotaro
AU  - Okanoue S
AD  - Department of Gastroenterology, Mitoyo General Hospital, Kanonji, 769‑1695, 
      Japan.
FAU - Yoshioka, Masao
AU  - Yoshioka M
AD  - Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, 
      700‑8511, Japan.
FAU - Sakaguchi, Chihiro
AU  - Sakaguchi C
AD  - Department of Gastroenterology, Shikoku Cancer Center, Matsuyama, 791-0280, 
      Japan.
FAU - Yamamoto, Kumiko
AU  - Yamamoto K
AD  - Department of Gastroenterology, Kagawa Prefectural Central Hospital, Takamatsu, 
      760‑8557, Japan.
FAU - Kawai, Yoshinari
AU  - Kawai Y
AD  - Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi, 722‑8503, 
      Japan.
FAU - Toyokawa, Tatsuya
AU  - Toyokawa T
AD  - Department of Gastroenterology, Fukuyama Medical Center, Fukuyama, 720‑8520, 
      Japan.
FAU - Tanaka, Takehiro
AU  - Tanaka T
AD  - Department of Pathology, Okayama University Hospital, Okayama, 700-8558, Japan.
FAU - Otsuka, Motoyuki
AU  - Otsuka M
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School 
      of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, 
      Okayama, 700-8558, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20240229
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
RN  - Familial primary gastric lymphoma
SB  - IM
MH  - Humans
MH  - *Lymphoma, B-Cell, Marginal Zone/genetics/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - Retrospective Studies
MH  - Neoplasm Recurrence, Local/genetics
MH  - Translocation, Genetic
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/genetics
MH  - *Lymphoma, Non-Hodgkin
MH  - *Stomach Neoplasms
PMC - PMC10902346
OTO - NOTNLM
OT  - Esophagogastroduodenoscopy
OT  - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
OT  - Gastric neoplasms
OT  - Trisomy 18
OT  - t(11;18) translocation
COIS- The authors declare no competing interests.
EDAT- 2024/02/29 00:42
MHDA- 2024/03/01 06:44
PMCR- 2024/02/29
CRDT- 2024/02/28 23:26
PHST- 2023/11/30 00:00 [received]
PHST- 2024/02/26 00:00 [accepted]
PHST- 2024/03/01 06:44 [medline]
PHST- 2024/02/29 00:42 [pubmed]
PHST- 2024/02/28 23:26 [entrez]
PHST- 2024/02/29 00:00 [pmc-release]
AID - 10.1038/s41598-024-55663-9 [pii]
AID - 55663 [pii]
AID - 10.1038/s41598-024-55663-9 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 29;14(1):4953. doi: 10.1038/s41598-024-55663-9.