PMID- 38419188
OWN - NLM
STAT- Publisher
LR  - 20240229
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
DP  - 2024 Feb 28
TI  - Diabetes mellitus and Alzheimer's disease: Vacuolar adenosine triphosphatase as a 
      potential link.
LID - 10.1111/ejn.16286 [doi]
AB  - Globally, the incidence of diabetes mellitus (DM) and Alzheimer's disease (AD) is 
      increasing year by year, causing a huge economic and social burden, and their 
      pathogenesis and aetiology have been proven to have a certain correlation. In 
      recent years, more and more studies have shown that vacuolar adenosine 
      triphosphatases (v-ATPases) in eukaryotes, which are biomolecules regulating 
      lysosomal acidification and glycolipid metabolism, play a key role in DM and AD. 
      This article describes the role of v-ATPase in DM and AD, including its role in 
      glycolysis, insulin secretion and insulin resistance (IR), as well as its 
      relationship with lysosomal acidification, autophagy and beta-amyloid (Abeta). In DM, 
      v-ATPase is involved in the regulation of glucose metabolism and IR. v-ATPase is 
      closely related to glycolysis. On the one hand, v-ATPase affects the rate of 
      glycolysis by affecting the secretion of insulin and changing the activities of 
      key glycolytic enzymes hexokinase (HK) and phosphofructokinase 1 (PFK-1). On the 
      other hand, glucose is the main regulator of this enzyme, and the assembly and 
      activity of v-ATPase depend on glucose, and glucose depletion will lead to its 
      decomposition and inactivation. In addition, v-ATPase can also regulate free 
      fatty acids, thereby improving IR. In AD, v-ATPase can not only improve the 
      abnormal brain energy metabolism by affecting lysosomal acidification and 
      autophagy but also change the deposition of Abeta by affecting the production and 
      degradation of Abeta. Therefore, v-ATPase may be the bridge between DM and AD.
CI  - (c) 2024 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Guo, Bin
AU  - Guo B
AUID- ORCID: 0000-0001-5199-5456
AD  - Key Laboratory of Basic Pharmacology of the Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of the Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Li, Qi-Ye
AU  - Li QY
AD  - Key Laboratory of Basic Pharmacology of the Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of the Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Liu, Xue-Jia
AU  - Liu XJ
AD  - Key Laboratory of Basic Pharmacology of the Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of the Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Luo, Guo-Hui
AU  - Luo GH
AD  - Key Laboratory of Basic Pharmacology of the Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of the Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Wu, Ya-Juan
AU  - Wu YJ
AD  - Key Laboratory of Basic Pharmacology of the Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of the Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Nie, Jing
AU  - Nie J
AD  - Key Laboratory of Basic Pharmacology of the Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of the Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
LA  - eng
GR  - 82260842/National Natural Science Foundation of China/
GR  - [2020]1Z075/Science and Technology Project Fund of Guizhou Province/
GR  - [2020]252/Key Laboratory of Basic Pharmacology of the Ministry of Education and 
      Joint International Research Laboratory of Ethnomedicine of the Ministry of 
      Education Funds/
PT  - Journal Article
PT  - Review
DEP - 20240228
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - diabetes mellitus
OT  - insulin resistance
OT  - vacuolar adenosine triphosphatases
OT  - beta-amyloid
EDAT- 2024/02/29 06:43
MHDA- 2024/02/29 06:43
CRDT- 2024/02/29 00:23
PHST- 2024/02/01 00:00 [revised]
PHST- 2023/12/01 00:00 [received]
PHST- 2024/02/02 00:00 [accepted]
PHST- 2024/02/29 06:43 [medline]
PHST- 2024/02/29 06:43 [pubmed]
PHST- 2024/02/29 00:23 [entrez]
AID - 10.1111/ejn.16286 [doi]
PST - aheadofprint
SO  - Eur J Neurosci. 2024 Feb 28. doi: 10.1111/ejn.16286.