PMID- 38419202
OWN - NLM
STAT- Publisher
LR  - 20240229
IS  - 1440-0960 (Electronic)
IS  - 0004-8380 (Linking)
DP  - 2024 Feb 28
TI  - Alterations in epidermal stem cells within the pilosebaceous unit in atrophic 
      acne scars.
LID - 10.1111/ajd.14224 [doi]
AB  - BACKGROUND: Atrophic acne scarring is a common sequela of inflammatory acne, 
      causing significant problems for affected patients. Although prolonged 
      inflammation and subsequent aberrant tissue regeneration are considered the 
      underlying pathogenesis, the role of epidermal stem cells, which are crucial to 
      the regeneration of pilosebaceous units, remains unknown. OBJECTIVES: To examine 
      the changes occurring in epidermal stem cells in atrophic acne scars. METHODS: 
      Changes in collagen, elastic fibre and human leukocyte antigen (HLA)-DR 
      expression were analysed in normal skin and inflammatory acne lesions at days 1, 
      3 and 7 after development. The expression of epidermal stem cell markers and 
      proliferation markers was compared between normal skin and mature atrophic acne 
      scar tissue. RESULTS: In acne lesions, inflammation had invaded into 
      pilosebaceous units over time. Their normal structure had been destructed and 
      replaced with a reduced amount of collagen and elastic fibre. Expression of stem 
      cell markers including CD34, p63, leucine-rich repeat-containing G 
      protein-coupled receptor (LGR)6 and LGR5, which are expressed in the 
      interfollicular epidermis, isthmus and bulge of hair follicles, significantly 
      decreased in atrophic acne scar tissue compared to normal skin. Epidermal 
      proliferation was significantly reduced in scar tissue. CONCLUSIONS: These 
      findings suggest that as inflammatory acne lesions progress, inflammation 
      gradually infiltrates the pilosebaceous unit and affects the resident stem cells. 
      This disruption impedes the normal regeneration of the interfollicular epidermis 
      and adnexal structures, resulting in atrophic acne scars.
CI  - (c) 2024 Australasian College of Dermatologists.
FAU - Kim, Dong Hyo
AU  - Kim DH
AUID- ORCID: 0000-0002-0501-5418
AD  - Department of Dermatology, Seoul National University College of Medicine, 
      Jongno-gu, Seoul, Korea.
AD  - Acne, Rosacea, Seborrheic Dermatitis and Hidradenitis Suppurativa Research 
      Laboratory, Seoul National University Hospital, Jongno-gu, Seoul, Korea.
FAU - Yoon, Ji Young
AU  - Yoon JY
AD  - Acne, Rosacea, Seborrheic Dermatitis and Hidradenitis Suppurativa Research 
      Laboratory, Seoul National University Hospital, Jongno-gu, Seoul, Korea.
FAU - Lee, Jun Hyo
AU  - Lee JH
AUID- ORCID: 0000-0003-3567-8922
AD  - Department of Dermatology, Seoul National University College of Medicine, 
      Jongno-gu, Seoul, Korea.
AD  - Acne, Rosacea, Seborrheic Dermatitis and Hidradenitis Suppurativa Research 
      Laboratory, Seoul National University Hospital, Jongno-gu, Seoul, Korea.
FAU - Suh, Dae Hun
AU  - Suh DH
AD  - Department of Dermatology, Seoul National University College of Medicine, 
      Jongno-gu, Seoul, Korea.
AD  - Acne, Rosacea, Seborrheic Dermatitis and Hidradenitis Suppurativa Research 
      Laboratory, Seoul National University Hospital, Jongno-gu, Seoul, Korea.
LA  - eng
GR  - 2020R1A2C1010987/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20240228
PL  - Australia
TA  - Australas J Dermatol
JT  - The Australasian journal of dermatology
JID - 0135232
SB  - IM
OTO - NOTNLM
OT  - acne
OT  - atrophic acne scar
OT  - epidermal stem cell
OT  - immunohistochemistry
EDAT- 2024/02/29 06:43
MHDA- 2024/02/29 06:43
CRDT- 2024/02/29 00:33
PHST- 2024/01/01 00:00 [revised]
PHST- 2023/10/04 00:00 [received]
PHST- 2024/02/04 00:00 [accepted]
PHST- 2024/02/29 06:43 [medline]
PHST- 2024/02/29 06:43 [pubmed]
PHST- 2024/02/29 00:33 [entrez]
AID - 10.1111/ajd.14224 [doi]
PST - aheadofprint
SO  - Australas J Dermatol. 2024 Feb 28. doi: 10.1111/ajd.14224.