PMID- 38419956
OWN - NLM
STAT- MEDLINE
DCOM- 20240301
LR  - 20240311
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 15
DP  - 2024
TI  - The combination of body mass index and fasting plasma glucose is associated with 
      type 2 diabetes mellitus in Japan: a secondary retrospective analysis.
PG  - 1355180
LID - 10.3389/fendo.2024.1355180 [doi]
LID - 1355180
AB  - BACKGROUND: Body mass index (BMI) and fasting plasma glucose (FPG) are known risk 
      factors for type 2 diabetes mellitus (T2DM), but data on the prospective 
      association of the combination of BMI and FPG with T2DM are limited. This study 
      sought to characterize the association of the combination of BMI and FPG (ByG) 
      with T2DM. METHODS: The current study used the NAGALA database. We categorized 
      participants by tertiles of ByG. The association of ByG with T2DM was expressed 
      with hazard ratios (HRs) with 95% confidence intervals (CIs) after adjustment for 
      potential risk factors. RESULTS: During a median follow-up of 6.19 years in the 
      normoglycemia cohort and 5.58 years in the prediabetes cohort, the incidence of 
      T2DM was 0.75% and 7.79%, respectively. Following multivariable adjustments, 
      there were stepwise increases in T2DM with increasing tertiles of ByG. After a 
      similar multivariable adjustment, the risk of T2DM was 2.57 (95% CI 2.26 - 2.92), 
      1.97 (95% CI 1.53 - 2.54) and 1.50 (95% CI 1.30 - 1.74) for a per-SD change in 
      ByG in all populations, the normoglycemia cohort and the prediabetes cohort, 
      respectively. CONCLUSION: ByG was associated with an increased risk of T2DM in 
      Japan. The result reinforced the importance of the combination of BMI and FPG in 
      assessing T2DM risk.
CI  - Copyright (c) 2024 Zhao, Yao, Song, Fan, Liu, Gao, Wang, Lu and Liu.
FAU - Zhao, Xiaofang
AU  - Zhao X
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Yao, Tianci
AU  - Yao T
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Song, Bei
AU  - Song B
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Fan, Haohui
AU  - Fan H
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Ting
AU  - Liu T
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Gao, Guangyu
AU  - Gao G
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Kun
AU  - Wang K
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Lu, Weilin
AU  - Lu W
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Chengyun
AU  - Liu C
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
LA  - eng
SI  - Dryad/10.5061%2Fdryad.8q0p192
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240214
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Body Mass Index
MH  - *Prediabetic State
MH  - Blood Glucose
MH  - Retrospective Studies
MH  - Japan/epidemiology
MH  - Fasting
PMC - PMC10899432
OTO - NOTNLM
OT  - Japan
OT  - body mass index
OT  - fasting plasma glucose
OT  - insulin resistance
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/29 06:42
MHDA- 2024/03/01 06:44
PMCR- 2024/01/01
CRDT- 2024/02/29 04:02
PHST- 2023/12/13 00:00 [received]
PHST- 2024/01/29 00:00 [accepted]
PHST- 2024/03/01 06:44 [medline]
PHST- 2024/02/29 06:42 [pubmed]
PHST- 2024/02/29 04:02 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2024.1355180 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2024 Feb 14;15:1355180. doi: 
      10.3389/fendo.2024.1355180. eCollection 2024.