PMID- 38420351
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240301
IS  - 2473-974X (Electronic)
IS  - 2473-974X (Linking)
VI  - 8
IP  - 1
DP  - 2024 Jan-Mar
TI  - Racial Disparities in Surgical Management For Early-Stage Laryngeal Squamous Cell 
      Carcinoma and Recurrent Dysplasia.
PG  - e119
LID - 10.1002/oto2.119 [doi]
LID - e119
AB  - OBJECTIVE: The aim of this study is to evaluate the association between race and 
      the treatment of laryngeal dysplasia and early-stage laryngeal squamous cell 
      carcinoma (LSCC). STUDY DESIGN: Retrospective Cohort Study. SETTING: Large 
      multispecialty academic medical center. METHODS: Patients were treated for 
      laryngeal dysplasia or LSCC between September 2019 and September 2022. A 
      retrospective chart review was conducted to collect demographic and clinical 
      information. Two-sample t tests, chi-square tests, and linear regression models 
      were used to compare characteristics (alpha = 0.05). Analyses were performed in STATA 
      17. RESULTS: Sixty-five patients were identified that underwent potassium titanyl 
      phosphate (KTP) transoral laser microsurgery for management of early-stage LSCC 
      (n = 29) or dysplasia (n = 36). The cohort consisted of 23 Black and 42 White 
      patients. No significant difference was found in age, alcohol or tobacco use, 
      rate of adjuvant radiotherapy, stage of disease, nor insurance status between the 
      2 groups. White patients underwent more procedures to address initial disease and 
      subsequent recurrent dysplasia on average than Black patients (2.52 vs 1.52, 
      P = .02). This remained true after adjusting for demographic and clinical 
      characteristics and insurance status in a linear regression model. While Black 
      patients were more likely to be lost to follow-up than White patients (30.4% vs 
      9.5%, P = .03), the average number of procedures between the groups still 
      differed significantly (2.63 vs 1.56, P = .04) when controlling for those lost to 
      follow-up. CONCLUSION: The findings presented here highlight potential inequities 
      that exist for racial minorities at early stages of treatment and in addressing 
      premalignant conditions, which may contribute to the known downstream disparities 
      in laryngeal cancer outcomes.
CI  - (c) 2024 The Authors. OTO Open published by Wiley Periodicals LLC on behalf of 
      American Academy of Otolaryngology-Head and Neck Surgery Foundation.
FAU - Cyberski, Thomas F
AU  - Cyberski TF
AUID- ORCID: 0000-0001-5774-3241
AD  - Pritzker School of Medicine The University of Chicago Chicago Illinois USA.
FAU - Wang, Alexander Z
AU  - Wang AZ
AD  - Pritzker School of Medicine The University of Chicago Chicago Illinois USA.
FAU - Baird, Brandon J
AU  - Baird BJ
AD  - Section of Otolaryngology-Head and Neck Surgery, Department of Surgery The 
      University of Chicago Medicine Chicago Illinois USA.
LA  - eng
PT  - Journal Article
DEP - 20240228
PL  - United States
TA  - OTO Open
JT  - OTO open
JID - 101717942
PMC - PMC10900919
OTO - NOTNLM
OT  - cancer
OT  - disparities
OT  - dysplasia
OT  - larynx
OT  - race
EDAT- 2024/02/29 06:42
MHDA- 2024/02/29 06:43
PMCR- 2024/02/28
CRDT- 2024/02/29 04:12
PHST- 2024/01/22 00:00 [received]
PHST- 2024/02/05 00:00 [accepted]
PHST- 2024/02/29 06:43 [medline]
PHST- 2024/02/29 06:42 [pubmed]
PHST- 2024/02/29 04:12 [entrez]
PHST- 2024/02/28 00:00 [pmc-release]
AID - OTO2119 [pii]
AID - 10.1002/oto2.119 [doi]
PST - epublish
SO  - OTO Open. 2024 Feb 28;8(1):e119. doi: 10.1002/oto2.119. eCollection 2024 Jan-Mar.