PMID- 38421440
OWN - NLM
STAT- Publisher
LR  - 20240229
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
DP  - 2024 Feb 20
TI  - Venoarterial Extracorporeal Membrane Oxygenation Implementation in Septic Shock 
      Rat Model.
LID - 10.1097/MAT.0000000000002168 [doi]
AB  - Septic shock, a global health concern, boasts high mortality rates. Research 
      exploring the efficacy of venoarterial extracorporeal membrane oxygenation 
      (VA-ECMO) in septic shock remains limited. Our study aimed to establish a rodent 
      model employing VA-ECMO in septic shock rats, assessing the therapeutic impact of 
      VA-ECMO on septic shock. Nineteen Sprague-Dawley rats were randomly assigned to 
      sham, septic shock, and (septic shock + VA-ECMO; SSE) groups. Septic shock was 
      induced by intravenous lipopolysaccharides, confirmed by a mean arterial pressure 
      drop to 25-30% of baseline. Rats in the SSE group received 2 hours of VA-ECMO 
      support and 60 minutes of post-weaning ventilation. Sham and septic shock groups 
      underwent mechanical ventilation for equivalent durations. Invasive mean arterial 
      pressure monitoring, echocardiographic examinations, and blood gas analysis 
      revealed the efficacy of VA-ECMO in restoring circulation and ensuring adequate 
      tissue oxygenation in septic shock rats. Post-experiment pathology exhibited the 
      potential of VA-ECMO in mitigating major organ injury. In summary, our study 
      successfully established a stable septic shock rat model with the implementation 
      of VA-ECMO, offering a valuable platform to explore molecular mechanisms 
      underlying VA-ECMO's impact on septic shock.
CI  - Copyright (c) 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the ASAIO.
FAU - Wang, Tianlong
AU  - Wang T
AD  - From the Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center 
      for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 
      China.
FAU - Zhang, Mingru
AU  - Zhang M
AD  - Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Dong, Wenhao
AU  - Dong W
AD  - Surgical IntensiveCare Unit, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Jing
AU  - Wang J
AD  - From the Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center 
      for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 
      China.
FAU - Zhang, Han
AU  - Zhang H
AD  - From the Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center 
      for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 
      China.
FAU - Wang, Yuefu
AU  - Wang Y
AD  - Surgical IntensiveCare Unit, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Ji, Bingyang
AU  - Ji B
AD  - From the Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center 
      for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240220
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
COIS- Disclosure: The authors have no conflicts of interest to report.
EDAT- 2024/02/29 12:42
MHDA- 2024/02/29 12:42
CRDT- 2024/02/29 11:07
PHST- 2024/02/29 12:42 [medline]
PHST- 2024/02/29 12:42 [pubmed]
PHST- 2024/02/29 11:07 [entrez]
AID - 00002480-990000000-00422 [pii]
AID - 10.1097/MAT.0000000000002168 [doi]
PST - aheadofprint
SO  - ASAIO J. 2024 Feb 20. doi: 10.1097/MAT.0000000000002168.