PMID- 38422691
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 389
DP  - 2024 Apr 15
TI  - Neuromodulator hydrogen sulfide attenuates sickness behavior induced by 
      lipopolysaccharide.
PG  - 578324
LID - S0165-5728(24)00042-0 [pii]
LID - 10.1016/j.jneuroim.2024.578324 [doi]
AB  - Sickness behavior reflects a state of altered physiology and central nervous 
      system function that occurs during systemic infection or inflammation, serving as 
      an adaptive response to illness. This study aims to elucidate the role of 
      hydrogen sulfide (H(2)S) in regulating sickness behavior and neuroinflammatory 
      responses in a rat model of systemic inflammation. Adult male Wistar rats were 
      treated with lipopolysaccharide (LPS) to induce sickness behavior. 
      Intracerebroventricular (i.c.v.) pretreatments included aminooxyacetic acid 
      (AOAA), an inhibitor of H(2)S synthesis, and sodium sulfide (NaHS), an H(2)S 
      donor. Behavioral assays were conducted, along with the assessment of astrocyte 
      activation, as indicated by GFAP expression in the hypothalamus. Pretreatment 
      with NaHS mitigated LPS-induced behavioral changes, including hypophagia, social 
      and exploratory deficits, without affecting peripheral cytokine levels, 
      indicating a central modulatory effect. AOAA, conversely, accentuated certain 
      behavioral responses, suggesting a complex role of endogenous H(2)S in sickness 
      behavior. These findings were reinforced by a lack of effect on plasma 
      interleukin levels but significant reduction in GFAP expression. Our findings 
      support the central role of H(2)S in modulating neuroinflammation and sickness 
      behavior, highlighting the therapeutic potential of targeting H(2)S signaling in 
      neuroinflammatory conditions.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Oliveira, Merelym K
AU  - Oliveira MK
AD  - Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Instituto de 
      Ciencias Biomedicas, Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, 
      Brazil.
FAU - Batista, Tatiane H
AU  - Batista TH
AD  - Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Instituto de 
      Ciencias Biomedicas, Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, 
      Brazil.
FAU - Rojas, Viviana Carolina T
AU  - Rojas VCT
AD  - Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Instituto de 
      Ciencias Biomedicas, Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, 
      Brazil.
FAU - Vitor-Vieira, Fernando
AU  - Vitor-Vieira F
AD  - Programa de Pos-Graduacao Multicentrico em Ciencias Fisiologicas, Instituto de 
      Ciencias Biomedicas, Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, 
      Brazil.
FAU - Reis, Leticia
AU  - Reis L
AD  - Programa de Pos-Graduacao em Biociencias, Instituto de Ciencias Biomedicas, 
      Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, Brazil.
FAU - Giusti, Fabiana Cardoso Vilela
AU  - Giusti FCV
AD  - Programa de Pos-Graduacao em Biociencias, Instituto de Ciencias Biomedicas, 
      Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, Brazil; Centro de 
      Inovacao e Ensaios Pre-Clinicos (CIEnP), Florianopolis, SC, Brazil.
FAU - Giusti-Paiva, Alexandre
AU  - Giusti-Paiva A
AD  - Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas, 
      Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil. Electronic 
      address: alexandre.giusti@ufsc.br.
LA  - eng
PT  - Journal Article
DEP - 20240224
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - YY9FVM7NSN (Hydrogen Sulfide)
RN  - 0 (Lipopolysaccharides)
RN  - FWU2KQ177W (sodium bisulfide)
RN  - 14I68GI3OQ (Aminooxyacetic Acid)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Sulfides)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Hydrogen Sulfide/pharmacology/therapeutic use
MH  - Lipopolysaccharides/toxicity
MH  - Illness Behavior
MH  - Rats, Wistar
MH  - Inflammation/chemically induced/drug therapy/metabolism
MH  - Aminooxyacetic Acid/pharmacology
MH  - Neurotransmitter Agents
MH  - *Sulfides
OTO - NOTNLM
OT  - Central nervous system
OT  - Cystathionine beta-synthase
OT  - Endotoxemia
OT  - Illness behavior
OT  - Neuroinflammation
COIS- Declaration of competing interest The authors report no biomedical financial 
      interests or other potential conflicts of interest.
EDAT- 2024/03/01 01:22
MHDA- 2024/04/08 06:43
CRDT- 2024/02/29 18:06
PHST- 2023/12/22 00:00 [received]
PHST- 2024/02/19 00:00 [revised]
PHST- 2024/02/22 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/03/01 01:22 [pubmed]
PHST- 2024/02/29 18:06 [entrez]
AID - S0165-5728(24)00042-0 [pii]
AID - 10.1016/j.jneuroim.2024.578324 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2024 Apr 15;389:578324. doi: 10.1016/j.jneuroim.2024.578324. Epub 
      2024 Feb 24.