PMID- 38422720
OWN - NLM
STAT- Publisher
LR  - 20240229
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 54
IP  - 3
DP  - 2024 Feb 28
TI  - Efficacy of spinal cord stimulation as an adjunctive therapy in heart failure: A 
      systematic review.
PG  - 102945
LID - S0987-7053(24)00003-0 [pii]
LID - 10.1016/j.neucli.2024.102945 [doi]
AB  - Neuromodulation therapy, like spinal cord stimulation (SCS), benefits individuals 
      with chronic diseases, improving outcomes of patients with heart failure (HF). 
      This systematic review aims to investigate the efficacy of SCS when used as an 
      adjunctive therapy in HF. A systematic analysis of all studies that included SCS 
      therapy in human participants with HF was conducted. After excluding studies not 
      meeting specific criteria, 4 studies involving a total of 125 participants were 
      selected. All participants had heart failure with the New York Heart Association 
      (NYHA) classification ranging from 2.2 +/- 0.4 to 3. The primary endpoints for 
      assessment included the impact of SCS in HF-related symptoms, Left ventricular 
      function, VO2 max, and NT-proBNP. All the studies could demonstrate safety and 
      feasibility of SCS therapy, although the outcomes varied. Two studies reported 
      improvement in NYHA classification, MLHFQ and QoL parameters after SCS. 
      Concerning LVEF and VO2 max, only one study indicated positive changes. None of 
      the studies found a significant change of NT-proBNP following SCS therapy. Given 
      methodological variation, discrepancies in the results could be attributed to the 
      diversity of the induction technique. Further studies are needed to develop a 
      solid approach for employing SCS in human patients with HF.
CI  - Copyright (c) 2024 Elsevier Masson SAS. All rights reserved.
FAU - Ashrafpour, Sahand
AU  - Ashrafpour S
AD  - Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
FAU - Ashrafpour, Manouchehr
AU  - Ashrafpour M
AD  - Mobility Impairment Research Center, Neuroscience Branch, Health Research 
      Institute and Department of Physiology, School of Medicine, Babol University of 
      Medical Sciences, Babol, Iran. Electronic address: m.ashrafpour@mubabol.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240228
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
OTO - NOTNLM
OT  - Heart failure
OT  - Neuromodulation
OT  - SCS
OT  - Spinal cord stimulation
COIS- Declaration of competing interest The authors declare that they have no competing 
      interest.
EDAT- 2024/03/01 01:22
MHDA- 2024/03/01 01:22
CRDT- 2024/02/29 18:07
PHST- 2023/11/25 00:00 [received]
PHST- 2024/01/09 00:00 [revised]
PHST- 2024/01/10 00:00 [accepted]
PHST- 2024/03/01 01:22 [medline]
PHST- 2024/03/01 01:22 [pubmed]
PHST- 2024/02/29 18:07 [entrez]
AID - S0987-7053(24)00003-0 [pii]
AID - 10.1016/j.neucli.2024.102945 [doi]
PST - aheadofprint
SO  - Neurophysiol Clin. 2024 Feb 28;54(3):102945. doi: 10.1016/j.neucli.2024.102945.