PMID- 38423165
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 544
DP  - 2024 Apr 19
TI  - Neurometabolic and Brain Functional Alterations Associated with Cognitive 
      Impairment in Patients with Myasthenia Gravis: A Combined (1)H-MRS and fMRI 
      Study.
PG  - 12-27
LID - S0306-4522(24)00085-X [pii]
LID - 10.1016/j.neuroscience.2024.02.021 [doi]
AB  - Whether patients with myasthenia gravis (MG) exhibit cognitive impairment is 
      controversial. Also the underlying mechanisms are unknown. We aimed to 
      investigate alterations in cognitive function, neurometabolite levels, and brain 
      function in patients with MG and to explore the associations between abnormal 
      regional brain functional activity, neurometabolite concentrations in the MPFC 
      and left thalamus, and cognitive activity in patients with MG. Neuropsychological 
      tests, proton magnetic resonance spectroscopy, and resting-state functional 
      magnetic resonance imaging were performed on 41 patients with MG and 45 race-, 
      sex-, age-, and education-matched healthy controls (HCs). The results suggest 
      that MG is accompanied by cognitive decline, as indicated by global cognitive 
      function, visual-spatial function, language, memory, abnormalities in regional 
      brain functional activity, and neurometabolite alterations (including GABA, NAA, 
      and Cho) in the medial prefrontal cortex (MPFC) and left thalamus. Cognitive 
      impairment in patients with MG may be related to abnormal regional brain 
      functional activity and changes in neurometabolites, and regional brain 
      functional activity may be modulated by specific neurometabolites.
CI  - Copyright (c) 2024 IBRO. Published by Elsevier Inc. All rights reserved.
FAU - Zhou, Xiaoling
AU  - Zhou X
AD  - Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China; Department of Neurology, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou, Jiangsu 215000, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical 
      University, Wuxi, Jiangsu 214000, China.
FAU - Zhu, Feng
AU  - Zhu F
AD  - Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China.
FAU - Chen, Xiang
AU  - Chen X
AD  - Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China.
FAU - Zhu, Yunfei
AU  - Zhu Y
AD  - Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China.
FAU - Gui, Tiantian
AU  - Gui T
AD  - Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China.
FAU - Li, Yonggang
AU  - Li Y
AD  - Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China. Electronic address: liyonggang224@163.com.
FAU - Xue, Qun
AU  - Xue Q
AD  - Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, China. Electronic address: qxue_sz@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240228
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Brain/diagnostic imaging
MH  - *Cognitive Dysfunction/diagnostic imaging
MH  - Proton Magnetic Resonance Spectroscopy/methods
MH  - *Myasthenia Gravis/complications/diagnostic imaging
OTO - NOTNLM
OT  - cognitive impairment
OT  - myasthenia gravis
OT  - proton magnetic resonance spectroscopy
OT  - resting-state functional magnetic resonance imaging
EDAT- 2024/03/01 01:22
MHDA- 2024/04/08 06:42
CRDT- 2024/02/29 19:14
PHST- 2023/08/04 00:00 [received]
PHST- 2024/01/04 00:00 [revised]
PHST- 2024/02/20 00:00 [accepted]
PHST- 2024/04/08 06:42 [medline]
PHST- 2024/03/01 01:22 [pubmed]
PHST- 2024/02/29 19:14 [entrez]
AID - S0306-4522(24)00085-X [pii]
AID - 10.1016/j.neuroscience.2024.02.021 [doi]
PST - ppublish
SO  - Neuroscience. 2024 Apr 19;544:12-27. doi: 10.1016/j.neuroscience.2024.02.021. 
      Epub 2024 Feb 28.