PMID- 38423282
OWN - NLM
STAT- Publisher
LR  - 20240314
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
DP  - 2024 Feb 27
TI  - Neonatal Nucleus Accumbens Microstructure Modulates Individual Susceptibility to 
      Preconception Maternal Stress in Relation to Externalizing Behaviors.
LID - S0890-8567(24)00071-6 [pii]
LID - 10.1016/j.jaac.2023.12.011 [doi]
AB  - OBJECTIVE: Maternal stress influences in utero brain development and is a 
      modifiable risk factor for offspring psychopathologies. Reward circuitry 
      dysfunction underlies various internalizing and externalizing psychopathologies. 
      This study examined (1) the association between maternal stress and 
      microstructural characteristics of the neonatal nucleus accumbens (NAcc), a major 
      node of the reward circuitry, and (2) whether neonatal NAcc microstructure 
      modulates individual susceptibility to maternal stress in relation to childhood 
      behavioral problems. METHOD: K-means longitudinal cluster analysis was performed 
      to determine trajectories of maternal stress measures (Perceived Stress Scale 
      [PSS], hair cortisol) from preconception to the third trimester. Neonatal NAcc 
      microstructural measures (orientation density index [ODI] and intracellular 
      volume fraction [ICVF]) were compared across trajectories. We then examined the 
      interaction between maternal stress and neonatal NAcc microstructure on child 
      internalizing and externalizing behaviors, assessed between ages 3 and 4 years. 
      RESULTS: Two trajectories of maternal stress magnitude ("low"/"high") were 
      identified for both PSS (n = 287) and hair cortisol (n = 336). Right neonatal 
      NAcc ODI (rNAcc-ODI) was significantly lower in "low" relative to "high" PSS 
      trajectories (n = 77, p = .04). PSS at preconception had the strongest 
      association with rNAcc-ODI (r = 0.293, p = .029). No differences in NAcc 
      microstructure were found between hair cortisol trajectories. A significant 
      interaction between preconception PSS and rNAcc-ODI on externalizing behavior was 
      observed (n = 47, p = .047). CONCLUSION: Our study showed that the preconception 
      period contributes to in utero NAcc development, and that NAcc microstructure 
      modulates individual susceptibility to preconception maternal stress in relation 
      to externalizing problems.
CI  - Copyright (c) 2024 American Academy of Child and Adolescent Psychiatry. Published 
      by Elsevier Inc. All rights reserved.
FAU - Chan, Shi Yu
AU  - Chan SY
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore.
FAU - Low, Xi Zhen
AU  - Low XZ
AD  - National University Health System, Singapore, Singapore.
FAU - Ngoh, Zhen Ming
AU  - Ngoh ZM
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore.
FAU - Ong, Zi Yan
AU  - Ong ZY
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore.
FAU - Kee, Michelle Z L
AU  - Kee MZL
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore.
FAU - Huang, Pei
AU  - Huang P
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore.
FAU - Kumar, Shivaram
AU  - Kumar S
AD  - National University of Singapore, Singapore, Singapore.
FAU - Rifkin-Graboi, Anne
AU  - Rifkin-Graboi A
AD  - National Institute of Education, Nanyang Technological University, Singapore, 
      Singapore.
FAU - Chong, Yap-Seng
AU  - Chong YS
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore; National University Health System, 
      Singapore, Singapore; National University of Singapore, Singapore, Singapore.
FAU - Chen, Helen
AU  - Chen H
AD  - KK Women's and Children's Hospital, Duke-National University of Singapore, 
      Singapore, Singapore.
FAU - Tan, Kok Hian
AU  - Tan KH
AD  - KK Women's and Children's Hospital, Duke-National University of Singapore, 
      Singapore, Singapore.
FAU - Chan, Jerry K Y
AU  - Chan JKY
AD  - KK Women's and Children's Hospital, Duke-National University of Singapore, 
      Singapore, Singapore.
FAU - Fortier, Marielle V
AU  - Fortier MV
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore; KK Women's and Children's Hospital, 
      Duke-National University of Singapore, Singapore, Singapore.
FAU - Gluckman, Peter D
AU  - Gluckman PD
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore; Liggins Institute, University of 
      Auckland, Auckland, New Zealand.
FAU - Zhou, Juan H
AU  - Zhou JH
AD  - National University of Singapore, Singapore, Singapore.
FAU - Meaney, Michael J
AU  - Meaney MJ
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore; National University of Singapore, 
      Singapore, Singapore; Douglas Mental Health University Institute, McGill 
      University, Montreal, Canada.
FAU - Tan, Ai Peng
AU  - Tan AP
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A *STAR), Singapore, Singapore; National University Health System, 
      Singapore, Singapore; National University of Singapore, Singapore, Singapore. 
      Electronic address: dnrtanap@nus.edu.sg.
LA  - eng
PT  - Journal Article
DEP - 20240227
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
SB  - IM
OTO - NOTNLM
OT  - Child Behavior Checklist
OT  - brain development
OT  - maternal factors
OT  - neuroimaging
OT  - stress
EDAT- 2024/03/01 01:22
MHDA- 2024/03/01 01:22
CRDT- 2024/02/29 19:17
PHST- 2023/03/16 00:00 [received]
PHST- 2023/11/20 00:00 [revised]
PHST- 2024/02/20 00:00 [accepted]
PHST- 2024/03/01 01:22 [pubmed]
PHST- 2024/03/01 01:22 [medline]
PHST- 2024/02/29 19:17 [entrez]
AID - S0890-8567(24)00071-6 [pii]
AID - 10.1016/j.jaac.2023.12.011 [doi]
PST - aheadofprint
SO  - J Am Acad Child Adolesc Psychiatry. 2024 Feb 27:S0890-8567(24)00071-6. doi: 
      10.1016/j.jaac.2023.12.011.