PMID- 38429134
OWN - NLM
STAT- MEDLINE
DCOM- 20240503
LR  - 20240504
IS  - 1873-3735 (Electronic)
IS  - 0165-6147 (Linking)
VI  - 45
IP  - 5
DP  - 2024 May
TI  - VMAT structures reveal exciting targets for drug development.
PG  - 385-387
LID - S0165-6147(24)00031-2 [pii]
LID - 10.1016/j.tips.2024.02.004 [doi]
AB  - Vesicular monoamine transporter (VMAT)-2 has a crucial role in the 
      neurotransmission of biogenic amines. Recently, Dalton et al., Pidathala et al., 
      Wu et al., and Wang et al. individually reported cryo-electron microscopy (EM) 
      structures of human VMAT2, offering opportunities for developing improved 
      therapeutics and deep insights into the functioning of this protein.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Schuldiner, Shimon
AU  - Schuldiner S
AD  - Department of Biological Chemistry, Institute of Life Sciences, Silberman Bldg. 
      1-513, Edmond J. Safra Campus, Hebrew University of Jerusalem, Givat Ram, 
      Jerusalem 91904, Israel. Electronic address: shimon.schuldiner@mail.huji.ac.il.
FAU - Forrest, Lucy R
AU  - Forrest LR
AD  - Computational Structural Biology Section, 35 Convent Drive, Room 3D-991, National 
      Institute of Neurological Disorders and Stroke, National Institutes of Health, 
      Bethesda, MD 20892-8202, USA. Electronic address: lucy.forrest@nih.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20240229
PL  - England
TA  - Trends Pharmacol Sci
JT  - Trends in pharmacological sciences
JID - 7906158
RN  - 0 (Vesicular Monoamine Transport Proteins)
RN  - 0 (SLC18A2 protein, human)
SB  - IM
MH  - *Vesicular Monoamine Transport Proteins/antagonists & inhibitors/metabolism
MH  - Humans
MH  - *Drug Development
MH  - *Cryoelectron Microscopy
MH  - Animals
OTO - NOTNLM
OT  - cryo-EM structure
OT  - neurotransmission
OT  - neurotransmitter transporter
OT  - synaptic vesicles
COIS- Declaration of interests None declared by authors.
EDAT- 2024/03/02 10:44
MHDA- 2024/05/04 11:50
CRDT- 2024/03/01 21:54
PHST- 2023/12/26 00:00 [received]
PHST- 2024/01/17 00:00 [revised]
PHST- 2024/02/16 00:00 [accepted]
PHST- 2024/05/04 11:50 [medline]
PHST- 2024/03/02 10:44 [pubmed]
PHST- 2024/03/01 21:54 [entrez]
AID - S0165-6147(24)00031-2 [pii]
AID - 10.1016/j.tips.2024.02.004 [doi]
PST - ppublish
SO  - Trends Pharmacol Sci. 2024 May;45(5):385-387. doi: 10.1016/j.tips.2024.02.004. 
      Epub 2024 Feb 29.