PMID- 38429373
OWN - NLM
STAT- MEDLINE
DCOM- 20240304
LR  - 20240304
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Mar 1
TI  - Hemifield-based analysis of pattern electroretinography in normal subjects and 
      patients with preperimetric glaucoma.
PG  - 5116
LID - 10.1038/s41598-024-55601-9 [doi]
LID - 5116
AB  - This prospective cross-sectional study investigated the visual function of 
      preperimetric glaucoma (PPG) patients based on hemifield (HF) pattern 
      electroretinogram (PERG) amplitudes. Thirty-two (32) normal subjects and 33 PPG 
      patients were enrolled in control and PPG groups, respectively. All of the 
      participants had undergone full ophthalmic examinations, including 
      spectral-domain optical coherence tomography (SD-OCT), visual field (VF) 
      examination and pattern electroretinography (PERG). The PERG parameters along 
      with the HF ratios of SD-OCT and PERG were compared between the control and PPG 
      groups. Pairwise Pearson's correlation coefficients and linear regression models 
      were fitted to investigate the correlations. The PERG N95 amplitudes were 
      significantly lower in the PPG group (P < 0.001). The smaller/larger HF N95 
      amplitude ratio of the PPG group was found to be smaller than that of the control 
      group (0.73 +/- 0.20 vs. 0.86 +/- 0.12; P = 0.003) and showed positive correlations 
      with affected HF average ganglion cell-inner plexiform layer (GCIPL) thickness 
      (r = 0.377, P = 0.034) and with average GCIPL thickness (r = 0.341, P = 0.005). 
      The smaller/larger HF N95 amplitude ratio did not significantly change with age 
      (beta =  - 0.005, P = 0.195), whereas the full-field N95 amplitude showed a negative 
      correlation with age (beta =  - 0.081, P < 0.001). HF analysis of PERG N95 
      amplitudes might be particularly useful for patients with early glaucoma.
CI  - (c) 2024. The Author(s).
FAU - Ahn, Eun Jung
AU  - Ahn EJ
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Daehakro Seoul Eye Clinic, Seoul, Korea.
FAU - Shin, Young In
AU  - Shin YI
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Ophthalmology, Gachon University Gil Hospital, Incheon, Korea.
FAU - Kim, Young Kook
AU  - Kim YK
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
FAU - Park, Ki Ho
AU  - Park KH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea. kihopark@snu.ac.kr.
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea. 
      kihopark@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20240301
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - *Electroretinography/methods
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Visual Field Tests/methods
MH  - *Glaucoma/diagnostic imaging
MH  - Tomography, Optical Coherence/methods
PMC - PMC10907379
COIS- The authors declare no competing interests.
EDAT- 2024/03/02 10:43
MHDA- 2024/03/04 06:48
PMCR- 2024/03/01
CRDT- 2024/03/01 23:21
PHST- 2023/12/11 00:00 [received]
PHST- 2024/02/26 00:00 [accepted]
PHST- 2024/03/04 06:48 [medline]
PHST- 2024/03/02 10:43 [pubmed]
PHST- 2024/03/01 23:21 [entrez]
PHST- 2024/03/01 00:00 [pmc-release]
AID - 10.1038/s41598-024-55601-9 [pii]
AID - 55601 [pii]
AID - 10.1038/s41598-024-55601-9 [doi]
PST - epublish
SO  - Sci Rep. 2024 Mar 1;14(1):5116. doi: 10.1038/s41598-024-55601-9.