PMID- 38431048 OWN - NLM STAT- Publisher LR - 20240309 IS - 2341-1929 (Electronic) IS - 2341-1929 (Linking) DP - 2024 Mar 1 TI - Adult respiratory distress syndrome (ARDS) due to omeprazole-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Case report and review of the literature. LID - S2341-1929(24)00046-5 [pii] LID - 10.1016/j.redare.2024.02.024 [doi] AB - Eosinophilia in not an uncommon findings in the intensive care unit (ICU); however, DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome, which is characterized by a hypersensitivity reaction to drugs and manifests as eosinophilia, systemic involvement and maculopapular erythematous rash 2-6 weeks after exposure to the offending drug, is an exceptional occurrence. We present the first case described in the literature of DRESS syndrome with pulmonary involvement in the form of interstitial pneumonitis and persistent adult respiratory distress syndrome (ARDS) secondary to proton pump inhibitors (PPI). The patient made a good recovery after withdrawal of the offending drug and long-term treatment with systemic corticosteroids. We also present a systematic review of all cases of DRESS with pulmonary involvement in the form of interstitial pneumonitis and cases of PPI-induced DRESS published to date; none of these describe pulmonary involvement. CI - Copyright (c) 2024. Publicado por Elsevier Espana, S.L.U. FAU - Diaz Diaz, D AU - Diaz Diaz D AD - Servicio de Medicina Intensiva, Hospital Universitario Infanta Leonor, Madrid, Spain. Electronic address: domingodiazdiaz@gmail.com. FAU - Olmos Mata, C AU - Olmos Mata C AD - Servico de Medicina Interna, Hospital Clinico San Carlos, Madrid, Spain. FAU - Palencia Herrejon, E AU - Palencia Herrejon E AD - Servicio de Medicina Intensiva, Hospital Universitario Infanta Leonor, Madrid, Spain. FAU - Lopez Perez, L AU - Lopez Perez L AD - Servicio de Medicina Intensiva, Hospital Universitario Infanta Leonor, Madrid, Spain. LA - eng PT - Case Reports DEP - 20240301 PL - Spain TA - Rev Esp Anestesiol Reanim (Engl Ed) JT - Revista espanola de anestesiologia y reanimacion JID - 101778594 SB - IM OTO - NOTNLM OT - Adult respiratory distress syndrome (ARDS) OT - DRESS syndrome OT - Eosinofilia OT - Eosinophilia OT - Fracaso multiorganico OT - Interstitial pneumonitis OT - Multi-organ failure OT - Neumonitis intersticial OT - Sindrome DRESS OT - Sindrome de distress respiratorio del adulto (SDRA) EDAT- 2024/03/03 17:42 MHDA- 2024/03/03 17:42 CRDT- 2024/03/02 19:15 PHST- 2023/07/28 00:00 [received] PHST- 2024/01/10 00:00 [accepted] PHST- 2024/03/03 17:42 [pubmed] PHST- 2024/03/03 17:42 [medline] PHST- 2024/03/02 19:15 [entrez] AID - S2341-1929(24)00046-5 [pii] AID - 10.1016/j.redare.2024.02.024 [doi] PST - aheadofprint SO - Rev Esp Anestesiol Reanim (Engl Ed). 2024 Mar 1:S2341-1929(24)00046-5. doi: 10.1016/j.redare.2024.02.024.