PMID- 38431237
OWN - NLM
STAT- MEDLINE
DCOM- 20240410
LR  - 20240410
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 118
DP  - 2024 May
TI  - Early-life matters: The role of fetal adrenal steroids in the relationship 
      between cytokines within the placental circulation and cognitive development 
      among infants in the Philippines.
PG  - 510-520
LID - S0889-1591(24)00280-0 [pii]
LID - 10.1016/j.bbi.2024.02.036 [doi]
AB  - Prenatal exposure to inflammation is related to the risk for cognitive impairment 
      in offspring. However, mechanisms underlying the link between inflammatory 
      cytokines at the maternal-fetal interface and human cognitive development are 
      largely unknown. This study addressed this research gap by examining whether i) 
      cytokines within the placenta are associated with different domains of 
      neurocognitive development during infancy, and ii) if DHEA-S in cord blood 
      mediates these associations. We also explored the role of early-life 
      socioeconomic status (SES) in moderating the effect of fetal adrenal steroids on 
      cognitive development in low- and middle-income country contexts. A cohort of 242 
      mother-infant dyads in Leyte, the Philippines participated in the study and all 
      of them were followed from early pregnancy until 12-months. Concentrations of 
      pro- and anti-inflammatory cytokines in the placenta, and DHEA-S in cord blood 
      collected at delivery were evaluated. The multifactorial aspects of the infant's 
      cognitive functioning were assessed based on the Bayley Scales of Infant 
      Development, third edition (BSID-III). We used Structural Equation Modelling 
      (SEM) with an orthogonal rotation to examine associated paths among latent 
      variables of pro- and anti-inflammatory cytokines in the placenta, fetal 
      neuroendocrine factors, and cognitive development. Pathway analyses showed that 
      both pro- and anti-inflammatory cytokines in the placenta were indirectly related 
      to cognitive (p < 0.05) and language developmental outcomes (p < 0.1) via DHEA-S 
      in cord blood among the low SES group. Yet, we found no statistically significant 
      indirect effect of pro- or anti-inflammatory cytokines on neurocognitive 
      development among the high SES sub-sample. This study extends our understanding 
      of how early-life socioeconomic conditions modify biological pathways underlying 
      the relationship between prenatal factors and postpartum cognitive development.
CI  - Copyright (c) 2024 Elsevier Inc. All rights reserved.
FAU - Lee, Yeonjin
AU  - Lee Y
AD  - Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of 
      Brown University, Providence, RI, United States; Department of Sociology, Kookmin 
      University, Seoul, South Korea. Electronic address: yjinlee@kookmin.ac.kr.
FAU - McDonald, Emily
AU  - McDonald E
AD  - Center for International Health Research, Rhode Island Hospital, Providence, RI, 
      United States; Department of Pediatrics, Warren Alpert Medical School of Brown 
      University, Providence, RI, United States.
FAU - Gundogan, Fusun
AU  - Gundogan F
AD  - Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of 
      Brown University, Providence, RI, United States.
FAU - Barry, Christopher V
AU  - Barry CV
AD  - Center for International Health Research, Rhode Island Hospital, Providence, RI, 
      United States; Warren Alpert Medical School of Brown University, Providence, RI, 
      United States.
FAU - Tallo, Veronica
AU  - Tallo V
AD  - Research Institute for Tropical Medicine, Manila, Philippines.
FAU - Colt, Susannah
AU  - Colt S
AD  - Center for International Health Research, Rhode Island Hospital, Providence, RI, 
      United States; Department of Pediatrics, Warren Alpert Medical School of Brown 
      University, Providence, RI, United States.
FAU - Friedman, Jennifer F
AU  - Friedman JF
AD  - Center for International Health Research, Rhode Island Hospital, Providence, RI, 
      United States; Warren Alpert Medical School of Brown University, Providence, RI, 
      United States; Department of Epidemiology, Brown University, Providence, RI, 
      United States; Department of Pediatrics, Warren Alpert Medical School of Brown 
      University, Providence, RI, United States.
LA  - eng
PT  - Journal Article
DEP - 20240301
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Cytokines)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Infant
MH  - Child
MH  - Humans
MH  - Pregnancy
MH  - Female
MH  - *Cytokines
MH  - *Placenta
MH  - Placental Circulation
MH  - Philippines
MH  - Cognition
MH  - Dehydroepiandrosterone
MH  - Anti-Inflammatory Agents
OTO - NOTNLM
OT  - DHEA-S
OT  - Neurocognitive development
OT  - Offspring
OT  - Placental cytokines
OT  - Socioeconomic status
OT  - Structural Equation Model
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/03 17:42
MHDA- 2024/04/10 06:43
CRDT- 2024/03/02 19:19
PHST- 2023/04/10 00:00 [received]
PHST- 2024/02/08 00:00 [revised]
PHST- 2024/02/28 00:00 [accepted]
PHST- 2024/04/10 06:43 [medline]
PHST- 2024/03/03 17:42 [pubmed]
PHST- 2024/03/02 19:19 [entrez]
AID - S0889-1591(24)00280-0 [pii]
AID - 10.1016/j.bbi.2024.02.036 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2024 May;118:510-520. doi: 10.1016/j.bbi.2024.02.036. Epub 
      2024 Mar 1.