PMID- 38431578
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240306
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Mar 2
TI  - Questionnaire-based study of COVID-19 vaccination induced headache: evidence of 
      clusters of adverse events.
PG  - 84
LID - 10.1186/s12883-024-03583-6 [doi]
LID - 84
AB  - BACKGROUND: The adverse events (AEs) after a Coronavirus disease 2019 (Covid-19) 
      Pfizer-Biotech mRNA vaccination present a medical and epidemiological issue of 
      increasing interest. Headache is the most frequent neurological adverse effect 
      and generally the third most common adverse event after a Covid-19 vaccination, 
      but only a few studies focus on the link between headache and other AEs after 
      vaccination. This study aims to investigate the correlation between headaches and 
      Covid-19 vaccination, as well as the possible links between headaches and other 
      AEs after Covid-19 vaccination, thereby helping the management of AEs and 
      avoiding further occurrences. METHODS: This study is based on a published 
      questionnaire survey of 1,402 healthcare workers. Our study focused on the 5 
      questions including 12 AEs and headaches extracted from the questionnaire post 
      the first and second Covid-19 vaccination. The severity of the 12 AEs and 
      headaches could be classified by the participants on a five-step scale: "Not at 
      all", "Little", "Average", "Quite", and "Very" (abbreviated as "N", "L", "A", 
      "Q", "V"). We used the Bowker test to study the comparison of headache severity, 
      indicated on a 5-point Likert scale between the first and second vaccinations. We 
      applied an ordinal logistic regression to the 5 categories with headache severity 
      serving as the dependent variable and the ratings of the other 12 AEs serving as 
      the independent variable to further explore to what extent the severity of the 12 
      AEs is associated with the severity of headaches. Receiver Operating 
      Characteristic (ROC) analysis was conducted to evaluate the predictive value of 
      the ratings of the 12 AEs to headache severity. RESULTS: We found that 
      participants rated their headaches as more severe after the second vaccination, 
      and participants who reported experiencing fatigue, flu-like symptoms, pain at 
      the injection site, known tension-type headache, fever, dizziness/balance 
      problems and known migraine are associated with headache symptoms. CONCLUSIONS: 
      There are clusters of headache-associated AEs post Covid-19 vaccination. The 
      association of various AEs with headaches may be due to similar causative 
      mechanisms.
CI  - (c) 2024. The Author(s).
FAU - Zhou, Qiao
AU  - Zhou Q
AD  - Department of Neurology, University Hospital, LMU Munich, Marchioninistr.15, 
      81377, Munich, Germany.
FAU - Eggert, Thomas
AU  - Eggert T
AD  - Department of Neurology, University Hospital, LMU Munich, Marchioninistr.15, 
      81377, Munich, Germany.
FAU - Zhelyazkova, Ana
AU  - Zhelyazkova A
AD  - Institut fur Notfallmedizin und Medizinmanagement, Klinikum der Universitat 
      Munchen, 80336, Munich, Germany.
FAU - Chouker, Alexander
AU  - Chouker A
AD  - Laboratory of Translational Research Stress and Immunity, Department of 
      Anaesthesiology, University Hospital Munich, Ludwig Maximilian University of 
      Munich, 81377, Munich, Germany.
FAU - Adorjan, Kristina
AU  - Adorjan K
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      80336, Munich, Germany.
FAU - Straube, Andreas
AU  - Straube A
AD  - Department of Neurology, University Hospital, LMU Munich, Marchioninistr.15, 
      81377, Munich, Germany. andreas.straube@med.uni-muenchen.de.
LA  - eng
PT  - Journal Article
DEP - 20240302
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - Humans
MH  - *COVID-19 Vaccines/adverse effects
MH  - *COVID-19/epidemiology/prevention & control/complications
MH  - Headache/epidemiology/etiology
MH  - Surveys and Questionnaires
MH  - Vaccination/adverse effects
PMC - PMC10908065
OTO - NOTNLM
OT  - Adverse events
OT  - Covid-19 vaccination
OT  - Headache
OT  - Side effects
COIS- The authors declare no competing interests.
EDAT- 2024/03/03 17:42
MHDA- 2024/03/05 06:46
PMCR- 2024/03/02
CRDT- 2024/03/02 23:15
PHST- 2023/10/31 00:00 [received]
PHST- 2024/02/23 00:00 [accepted]
PHST- 2024/03/05 06:46 [medline]
PHST- 2024/03/03 17:42 [pubmed]
PHST- 2024/03/02 23:15 [entrez]
PHST- 2024/03/02 00:00 [pmc-release]
AID - 10.1186/s12883-024-03583-6 [pii]
AID - 3583 [pii]
AID - 10.1186/s12883-024-03583-6 [doi]
PST - epublish
SO  - BMC Neurol. 2024 Mar 2;24(1):84. doi: 10.1186/s12883-024-03583-6.