PMID- 38431589
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240306
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Mar 2
TI  - Can prolonged P-R interval predict clinical outcomes in non-ST elevation acute 
      coronary syndrome patients?
PG  - 137
LID - 10.1186/s12872-024-03809-y [doi]
LID - 137
AB  - BACKGROUND: The present study aimed to respond to clinical question, can 
      prolonged P-R interval predict clinical outcomes in non-ST elevation acute 
      coronary syndrome patients? METHODS: This descriptive-analytical study was 
      conducted on cardiac patients. All of the non-ST elevation acute coronary 
      syndrome (NSTEACS) including non-ST elevation myocardial infarction (NSTEMI) and 
      unstable angina patients included in the study. Then they divided into two 
      groups: prolonged P-R interval and normal P-R interval. The patients who had a 
      history of digoxin and calcium channel blocker use, using antiarrhythmic drugs, 
      known valvular or congenital heart disease and connective tissue, unreadable P-R 
      interval and cardiac block were excluded. Data were collected using the 
      questionnaire consisted demographic data and clinical outcomes and a follow-up 
      part was completed by one of the researchers. RESULTS: Finally, 248 patients 
      completed the study. The results showed both of the two groups had significant 
      differences in terms of the history of myocardial infarction (MI) (p = 0.018), 
      the level of high-density lipoprotein (HDL) (p = 0.004), heart rate (p = 0.042), 
      inverted T wave (p = 0.017), anterior ST- segment depression (p = 0.008), normal 
      report of coronary angiography (CAG) (p = 0.003), three vessels disease 
      (p = 0.043), left main lesion (p = 0.045) and SYNTAX score (p = 0.032) based on 
      the CAG report. The results of six-month follow-up showed although, the frequency 
      of ischemic stroke, coronary artery disease (CAD) and cardiovascular death were 
      higher in prolonged P-R interval groups. The chi-square test showed this 
      difference was statistically non-significant (p > 0.05). The multivariate 
      logistic regression model revealed non-significant relationships between 
      prolonged P-R interval and SYNTAX score, significant CAD, three-vessel disease, 
      inverted T wave, anterior ST depression, heart rate and HDL. CONCLUSIONS: Based 
      on the results of our study the six-month follow-up showed non-significant 
      outcomes. Further studies are recommended to assess the long-term outcomes.
CI  - (c) 2024. The Author(s).
FAU - Zareei, Mohammad
AU  - Zareei M
AD  - Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.
FAU - Zareiamand, Hossein
AU  - Zareiamand H
AD  - Department of Cardiology, Faculty of medicine, Islamic Azad University, Sari 
      branch, Sari, Iran.
FAU - Kamali, Mahsa
AU  - Kamali M
AD  - Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, 
      Iran.
FAU - Ardalani, Nasim
AU  - Ardalani N
AD  - Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.
FAU - Ebrahimi, Ata
AU  - Ebrahimi A
AD  - Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.
FAU - Nabati, Maryam
AU  - Nabati M
AD  - Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, 
      Mazandaran University of Medical Sciences, Sari, Iran. Dr.mr.nabati@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240302
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Humans
MH  - *Acute Coronary Syndrome/diagnostic imaging/therapy
MH  - *Myocardial Infarction
MH  - *Coronary Artery Disease
MH  - Angina, Unstable/diagnosis
MH  - *Non-ST Elevated Myocardial Infarction/diagnostic imaging/therapy
MH  - Coronary Angiography/methods
MH  - Heart Block
MH  - Electrocardiography
PMC - PMC10909255
OTO - NOTNLM
OT  - Clinical outcome
OT  - Coronary angiography
OT  - Echocardiography
OT  - Electrocardiography
OT  - P-R interval
OT  - ST-elevation
COIS- The authors declare no competing interests.
EDAT- 2024/03/03 17:42
MHDA- 2024/03/05 06:47
PMCR- 2024/03/02
CRDT- 2024/03/02 23:15
PHST- 2023/11/09 00:00 [received]
PHST- 2024/02/21 00:00 [accepted]
PHST- 2024/03/05 06:47 [medline]
PHST- 2024/03/03 17:42 [pubmed]
PHST- 2024/03/02 23:15 [entrez]
PHST- 2024/03/02 00:00 [pmc-release]
AID - 10.1186/s12872-024-03809-y [pii]
AID - 3809 [pii]
AID - 10.1186/s12872-024-03809-y [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2024 Mar 2;24(1):137. doi: 10.1186/s12872-024-03809-y.