PMID- 38431956
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240308
IS  - 1735-3947 (Electronic)
IS  - 1029-2977 (Print)
IS  - 1029-2977 (Linking)
VI  - 27
IP  - 1
DP  - 2024 Jan 1
TI  - Reference Interval for Non-HDL-Cholesterol, Remnant Cholesterol and Other Lipid 
      Parameters in the Southern Iranian Population; Findings From Bandare Kong and 
      Fasa Cohort Studies.
PG  - 15-22
LID - 10.34172/aim.2024.03 [doi]
AB  - BACKGROUND: Growing evidence shows the undisputable role of non-HDL-C and remnant 
      cholesterol (remnant-C) in cardiovascular disease (CVD) risk assessment and 
      treatment. However, the reference interval (RI) for these lipid parameters is not 
      readily available. The aim of the present investigation was to determine the age 
      and sex-specific RIs for non-HDL-C and remnant-C as well as other lipid 
      parameters among a healthy population in southern Iran. We also report the RI of 
      lipid parameters in rural and urban residents, smokers and post-menopausal women. 
      METHODS: Among 14063 participants of Bandare Kong and Fasa cohort studies, 792 
      healthy subjects (205 men and 578 women) aged 35-70 years were selected. Fasting 
      blood samples were used for determination of total cholesterol (TC), 
      triglycerides (TG) and HDL-C using colorimetric methods. Non-HDL-C and remnant-C 
      were calculated using the valid formula. The 2.5th and 97.5th percentiles were 
      calculated and considered as RI. RESULTS: In the total population (n=792, age 
      35-70), RIs for non-HDL-C and remnant-C was 74.0-206.8 and 8.0-52.7 mg/dL, 
      respectively. Age (35-44 and>/=45 years) and gender-specific RIs for serum 
      non-HDL-C and remnant-C were determined. Remnant-C and non-HDL-C level were 
      different between sex and age categories. The mean value of all lipid parameters 
      except HDL-C was higher in men, urban residents, subject with age>/=45 years and 
      smokers. CONCLUSION: This is the first study in which the RIs for non-HDL-C and 
      remnant-C in southern Iran are reported. This may help physicians to conveniently 
      use these lipid parameters for patient care and better cardiovascular risk 
      assessment.
CI  - (c) 2024 The Author(s). This is an open-access article distributed under the terms 
      of the Creative Commons Attribution License 
      (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, 
      distribution, and reproduction in any medium, provided the original work is 
      properly cited.
FAU - Farjam, Mojtaba
AU  - Farjam M
AUID- ORCID: 0000-0003-4826-2846
AD  - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, 
      Fasa, Iran.
FAU - Kheirandish, Masoumeh
AU  - Kheirandish M
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Ghanbarnejad, Amin
AU  - Ghanbarnejad A
AD  - Social Determinants in Health Promotion Research Center, Faculty of Health, 
      Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
FAU - Nikpoor, Amin Reza
AU  - Nikpoor AR
AD  - Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan 
      University of Medical Sciences, Bandar Abbas, Iran.
FAU - Nejatizadeh, Abdolazim
AU  - Nejatizadeh A
AD  - Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan 
      University of Medical Sciences, Bandar Abbas, Iran.
FAU - Aghamolaei, Teymour
AU  - Aghamolaei T
AD  - Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar 
      Abbas, Iran.
FAU - Shahmoradi, Mehdi
AU  - Shahmoradi M
AD  - Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan 
      University of Medical Sciences, Bandar Abbas, Iran.
FAU - Alizade, Hesam
AU  - Alizade H
AD  - Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, 
      Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
FAU - Homayounfar, Reza
AU  - Homayounfar R
AD  - National Nutrition and Food Technology Research Center, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Zarei, Hassan
AU  - Zarei H
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Ghavidel, Sahar
AU  - Ghavidel S
AD  - Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan 
      University of Medical Sciences, Bandar Abbas, Iran.
FAU - Jamshidi, Vahide
AU  - Jamshidi V
AD  - Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan 
      University of Medical Sciences, Bandar Abbas, Iran.
FAU - Eftekhar, Ebrahim
AU  - Eftekhar E
AUID- ORCID: 0000-0002-4519-0595
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
LA  - eng
PT  - Journal Article
DEP - 20240101
PL  - Iran
TA  - Arch Iran Med
JT  - Archives of Iranian medicine
JID - 100889644
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Iran/epidemiology
MH  - *Cholesterol
MH  - Triglycerides
MH  - Cohort Studies
MH  - *Health Status
PMC - PMC10915932
OTO - NOTNLM
OT  - Lipid profile
OT  - Non-HDL Cholesterol
OT  - Reference interval
OT  - Remnant cholesterol
COIS- Competing Interests The authors declare that they have no competing interests.
EDAT- 2024/03/03 19:47
MHDA- 2024/03/05 06:44
PMCR- 2024/01/01
CRDT- 2024/03/03 16:30
PHST- 2022/11/07 00:00 [received]
PHST- 2023/09/19 00:00 [accepted]
PHST- 2024/03/05 06:44 [medline]
PHST- 2024/03/03 19:47 [pubmed]
PHST- 2024/03/03 16:30 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.34172/aim.2024.03 [doi]
PST - epublish
SO  - Arch Iran Med. 2024 Jan 1;27(1):15-22. doi: 10.34172/aim.2024.03.