PMID- 38432930
OWN - NLM
STAT- Publisher
LR  - 20240303
IS  - 1347-3409 (Electronic)
IS  - 1345-4676 (Linking)
DP  - 2024 Mar 2
TI  - Oxidative stress and antioxidant capacity in patients with endometrioma.
LID - 10.1272/jnms.JNMS.2024_91-204 [doi]
AB  - BackgroundEndometriosis has several clinical features, including dysmenorrhea, 
      infertility, and endometrioma (EMO). Although oxidative stress status is closely 
      related to endometriosis, it is unclear how the balance between oxidative stress 
      capacity and antioxidant capacity correlates with treatment of or factors that 
      worsen endometriosis. In this study, we used peritoneal fluid from patients with 
      EMO to investigate the role of oxidative stress capacity and antioxidant 
      capacity.Materials and MethodsParticipants with EMO (n = 30) and without EMO 
      (uterine myoma, n = 13) were enrolled. All peritoneal fluid samples were 
      collected at the beginning of surgery. We evaluated oxidative stress capacity and 
      antioxidant capacity in peritoneal fluid samples by using the diacron-reactive 
      oxygen metabolites (d-ROM) and biological antioxidant potential (BAP) tests, 
      respectively. The d-ROM and BAP values and the d-ROM/BAP ratio were measured, and 
      their correlations with the CA125 level, revised American Society for 
      Reproductive Medicine (r-ASRM) score, and tumor size were analyzed.ResultsThe 
      d-ROM/BAP ratio was significantly higher in patients with EMO than in those 
      without EMO. In addition, the d-ROM/BAP ratio was positively correlated with 
      CA125 level and r-ASRM scores in patients with EMO.ConclusionsOxidative stress is 
      correlated with factors that worsen EMO. The d-ROM/BAP test may be useful for 
      assessing disease status in patients with EMO.
FAU - Ichikawa, Go
AU  - Ichikawa G
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
AD  - Department of Obstetrics and Gynecology, Chiba Hokusoh Hospital, Nippon Medical 
      School.
FAU - Negishi, Yasuyuki
AU  - Negishi Y
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
AD  - Department of Microbiology and Immunology, Nippon Medical School.
FAU - Tsuchiya, Ryo
AU  - Tsuchiya R
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
FAU - Higuchi, Lilika
AU  - Higuchi L
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
FAU - Shiraishi, Tatsunori
AU  - Shiraishi T
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
FAU - Ikeda, Mariko
AU  - Ikeda M
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
FAU - Kaseki, Hanako
AU  - Kaseki H
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
AD  - Department of Obstetrics and Gynecology, Chiba Hokusoh Hospital, Nippon Medical 
      School.
FAU - Morita, Rimpei
AU  - Morita R
AD  - Department of Microbiology and Immunology, Nippon Medical School.
FAU - Suzuki, Shunji
AU  - Suzuki S
AD  - Department of Obstetrics and Gynecology, Nippon Medical School.
LA  - eng
PT  - Journal Article
DEP - 20240302
PL  - Japan
TA  - J Nippon Med Sch
JT  - Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
JID - 100935589
SB  - IM
OTO - NOTNLM
OT  - endometrioma
OT  - endometriosis
OT  - oxidative stress
EDAT- 2024/03/04 00:43
MHDA- 2024/03/04 00:43
CRDT- 2024/03/03 21:14
PHST- 2024/03/04 00:43 [medline]
PHST- 2024/03/04 00:43 [pubmed]
PHST- 2024/03/03 21:14 [entrez]
AID - 10.1272/jnms.JNMS.2024_91-204 [doi]
PST - aheadofprint
SO  - J Nippon Med Sch. 2024 Mar 2. doi: 10.1272/jnms.JNMS.2024_91-204.