PMID- 38433051
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 53
IP  - 3
DP  - 2024 Mar 8
TI  - [Clinical, imaging and pathological and molecular characteristics of simple bone 
      cyst].
PG  - 243-249
LID - 10.3760/cma.j.cn112151-20231014-00260 [doi]
AB  - Objective: To investigate the radiologic, pathologic, and molecular features of 
      simple bone cysts (SBC), and their differential diagnoses. Methods: Fourteen 
      cases of SBC were collected at the Department of Pathology, the First Affiliated 
      Hospital of Nanjing Medical University from 2017 to 2022, and fluorescence in 
      situ hybridization (FISH) was performed for retrospective analysis. Results: 
      There were 14 patients, including 7 females and 7 males, with age range of 7 to 
      45 (median 29) years. The most common complaint was pain, including 4 cases with 
      pathological fracture and 5 with history of previous trauma. The tumor size 
      ranged from 3.4 to 13.5 (median 5.6) cm. The lesion involved the femur (n=4), 
      humerus (n=5) and iliac bone (n=5). Radiologic diagnoses included SBC, aneurysmal 
      bone cyst, and giant cell tumor of the bone or its combination with aneurysmal 
      bone cyst-like region and fibrous dysplasia. Histologically, the cyst walls of 
      the lesions were composed of fibrous tissue, fibrin-like collagen deposits, 
      bone-like matrix and occasional woven bone. The lesional cells were spindled to 
      ovoid, with scattered osteoclast-like giant cells, foamy histiocytes, hemosiderin 
      deposits and cholesterol clefts. In 6 cases there were nodular fasciitis-like 
      areas. Immunohistochemically, the spindled to ovoid cells were positive for SMA, 
      EMA and SATB2 in varying degrees. FISH detection was performed in all 14 cases 
      and EWSR1/FUS rearrangement were found in 9 cases. One case of FUS::NFATC2 fusion 
      was detected by next-generation sequencing. Nine cases of SBC with the 
      rearrangement were more cellular, and there were more mitotic figures in the 
      recurrent FUS::NFATC2 fusion tumor. Clinical follow-up was obtained in all 14 
      cases with the time ranging from 5 to 105 (mean 46) months. Amongst them, the 
      tumor with FUS::NFATC2 rearrangement had local recurrence twice after the first 
      local excision, but had no more recurrence or metastasis 34 months after the 
      subsequent segmental resection. The other 13 cases had no recurrence. 
      Conclusions: EWSR1 or FUS rearrangement is most commonly identified in SBC, 
      suggesting that SBC might be a neoplastic disease. In cases where the radiologic 
      appearance and histomorphology are difficult to differentiate from aneurysmal 
      bone cyst, FISH detection can aid in the definitive diagnosis.
FAU - Yang, X X
AU  - Yang XX
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing 210029, China.
FAU - Sheng, S J
AU  - Sheng SJ
AD  - Department of Pathology, the First People's Hospital of Changzhou, Changzhou 
      213000, China.
FAU - Zou, Y F
AU  - Zou YF
AD  - Department of Imaging, the First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing 210029, China.
FAU - Zhu, Y
AU  - Zhu Y
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing 210029, China.
FAU - Ding, Y
AU  - Ding Y
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing 210029, China.
FAU - Fan, Q H
AU  - Fan QH
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing 210029, China.
FAU - Gong, Q X
AU  - Gong QX
AD  - Department of Pathology, the First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing 210029, China.
LA  - chi
GR  - JSHD2022040/Jiangsu Health Development Research Center open project/
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Female
MH  - Male
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - Middle Aged
MH  - *Bone Cysts, Aneurysmal/diagnostic imaging/genetics/surgery
MH  - In Situ Hybridization, Fluorescence
MH  - Retrospective Studies
MH  - *Bone Cysts/diagnostic imaging/genetics
MH  - Diagnosis, Differential
EDAT- 2024/03/04 00:44
MHDA- 2024/03/05 06:46
CRDT- 2024/03/03 21:53
PHST- 2024/03/05 06:46 [medline]
PHST- 2024/03/04 00:44 [pubmed]
PHST- 2024/03/03 21:53 [entrez]
AID - 10.3760/cma.j.cn112151-20231014-00260 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2024 Mar 8;53(3):243-249. doi: 
      10.3760/cma.j.cn112151-20231014-00260.