PMID- 38433053
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 53
IP  - 3
DP  - 2024 Mar 8
TI  - [Correlation of 1p/16q loss of heterozygosity and 1p gain with 
      clinicopathological characteristics and prognosis in Wilms tumor].
PG  - 257-263
LID - 10.3760/cma.j.cn112151-20230814-00066 [doi]
AB  - Objective: To investigate the relationship between 1p/16q loss of heterozygosity 
      (LOH) and 1p gain in Wilms tumor and their clinicopathologic characteristics and 
      prognosis. Methods: A total of 175 Wilms tumor samples received from the 
      Department of Pathology, Beijing Children's Hospital from September 2019 to 
      August 2022 were retrospectively analyzed. The histopathologic type and presence 
      of lymph node involvement were evaluated by two pathologists. The clinical data 
      including patients'gender, age, tumor location, preoperative chemotherapy, and 
      tumor stage were summarized. Fluorescence in situ hybridization (FISH) was done 
      to detect 1p/16q LOH and 1p gain and their correlation with the 
      clinicopathological features and prognosis were analyzed. Results: Among the 175 
      samples, 86 cases (49.1%) were male and 89 (50.9%) were female. The mean age was 
      (3.5+/-2.9) years, and the median age was 2.6 years. There were 26 (14.9%) cases 
      with 1p LOH, 28 (16.0%) cases with 16q LOH, 10 (5.7%) cases of LOH at both 1p and 
      16q, and 53 (30.3%) cases with 1q gain. 1q gain was significantly associated with 
      1p LOH (P<0.01) and 16q LOH (P<0.01). There were significant differences (P<0.01) 
      between 1q gain, 1p LOH and 16q LOH among different age groups. The rate of 16q 
      LOH in the high-risk histopathological subtype (50.0%) was significantly higher 
      than that in the intermediate-risk subtype (13.6%, P<0.05). The frequency of 1q 
      gain, 1p LOH, and 16q LOH in children with advanced clinical stages (Ⅲ and Ⅳ) was 
      significantly higher than that in children with early clinical stages (Ⅰ and Ⅱ). 
      1q gain, 1p LOH, and 16q LOH showed no significant correlation with gender, 
      unilateral or bilateral disease, chemotherapy, or lymph node metastasis. The 
      progression-free survival (PFS) time for patients with 1q gain and 1p LOH was 
      significantly shorter than those without these aberrations (P<0.05). 
      Additionally, the PFS time of patients with 16q LOH was slightly shorter than 
      those with normal 16q, although the difference was not statistically significant. 
      Patients with stage Ⅲ to Ⅳ disease exhibiting 1q gain or 1p LOH had a 
      significantly higher relative risk of recurrence, metastasis, and mortality. 
      Conclusions: 1p/16q LOH and 1q gain are associated with age, high-risk 
      histological type, and clinical stage in Wilms tumor. 1q gain and 1p LOH are 
      significantly correlated with the prognosis of Wilms tumor.
FAU - Jia, C
AU  - Jia C
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
FAU - Yao, X F
AU  - Yao XF
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
FAU - Zhang, M
AU  - Zhang M
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
FAU - Guan, X X
AU  - Guan XX
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
FAU - Wang, J W
AU  - Wang JW
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
FAU - Song, H C
AU  - Song HC
AD  - Department of Urology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
FAU - He, L J
AU  - He LJ
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing 100045, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Child
MH  - Humans
MH  - Female
MH  - Male
MH  - Child, Preschool
MH  - Infant
MH  - In Situ Hybridization, Fluorescence
MH  - Retrospective Studies
MH  - Prognosis
MH  - *Wilms Tumor/genetics
MH  - Chromosome Aberrations
MH  - *Kidney Neoplasms/genetics
MH  - Loss of Heterozygosity
EDAT- 2024/03/04 00:44
MHDA- 2024/03/05 06:45
CRDT- 2024/03/03 21:53
PHST- 2024/03/05 06:45 [medline]
PHST- 2024/03/04 00:44 [pubmed]
PHST- 2024/03/03 21:53 [entrez]
AID - 10.3760/cma.j.cn112151-20230814-00066 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2024 Mar 8;53(3):257-263. doi: 
      10.3760/cma.j.cn112151-20230814-00066.