PMID- 38433545
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240313
IS  - 2308-1430 (Electronic)
IS  - 0375-9660 (Print)
IS  - 0375-9660 (Linking)
VI  - 70
IP  - 1
DP  - 2024 Feb 28
TI  - [Fixed ratio combinations GLP-1RA and basal insulin: literature review].
PG  - 91-99
LID - 10.14341/probl13312 [doi]
AB  - The progressive nature of type 2 diabetes mellitus leads to the need for insulin 
      therapy in a significant proportion of patients. Very often start of insulin 
      therapy in type 2 diabetes mellitus (T2DM) is associated with weight gain and a 
      significant increase of hypoglycemia's risk. However, innovative options, such as 
      fixed ratio combinations of glucagon-like peptide 1 receptor agonists (GLP-1RA) 
      and basal insulin, minimize weight gain and hypoglycemia risks and allow a 
      greater proportion of patients to achieve individual glycemic control goals 
      without compromising safety parameters. This review includes a description of the 
      randomized clinical trials, as well as the results of real clinical practice of 
      the use of two currently existing fixed ration combinations of GLP-1RA and basal 
      insulin - iDegLira and iGlarLixi.
FAU - Kurkin, D V
AU  - Kurkin DV
AD  - Russian University of Medicine; Volgograd State Medical University.
FAU - Bakulin, D A
AU  - Bakulin DA
AD  - Russian University of Medicine.
FAU - Morkovin, E I
AU  - Morkovin EI
AD  - Volgograd State Medical University.
FAU - Strygin, A V
AU  - Strygin AV
AD  - Volgograd State Medical University.
FAU - Gorbunova, Ju V
AU  - Gorbunova JV
AD  - Russian University of Medicine.
FAU - Volotova, E V
AU  - Volotova EV
AD  - Volgograd State Medical University.
FAU - Robertus, A I
AU  - Robertus AI
AD  - Russian University of Medicine.
FAU - Makarenko, I E
AU  - Makarenko IE
AD  - Russian University of Medicine; CJSC <<Farm-Holding>>.
FAU - Saparova, V B
AU  - Saparova VB
AD  - Russian University of Medicine; CJSC <<Farm-Holding>>.
FAU - Drai, R V
AU  - Drai RV
AD  - CJSC <<Farm-Holding>>.
FAU - Petrov, V I
AU  - Petrov VI
AD  - Volgograd State Medical University.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
DEP - 20240228
PL  - Russia (Federation)
TA  - Probl Endokrinol (Mosk)
JT  - Problemy endokrinologii
JID - 0140673
RN  - 0 (Insulin)
RN  - 0 (Insulin, Regular, Human)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Insulin/therapeutic use
MH  - Insulin, Regular, Human
MH  - *Hypoglycemia/chemically induced
MH  - Weight Gain
PMC - PMC10926250
EDAT- 2024/03/04 06:46
MHDA- 2024/03/05 06:44
PMCR- 2024/02/28
CRDT- 2024/03/04 02:33
PHST- 2023/05/25 00:00 [received]
PHST- 2023/08/10 00:00 [accepted]
PHST- 2023/07/06 00:00 [revised]
PHST- 2024/03/05 06:44 [medline]
PHST- 2024/03/04 06:46 [pubmed]
PHST- 2024/03/04 02:33 [entrez]
PHST- 2024/02/28 00:00 [pmc-release]
AID - 10.14341/probl13312 [doi]
PST - epublish
SO  - Probl Endokrinol (Mosk). 2024 Feb 28;70(1):91-99. doi: 10.14341/probl13312.