PMID- 38433849
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240305
IS  - 1179-5549 (Print)
IS  - 1179-5549 (Electronic)
IS  - 1179-5549 (Linking)
VI  - 18
DP  - 2024
TI  - Association Between Multiple Single Nucleotide Polymorphisms in Folate Metabolism 
      Pathway and Breast Cancer Risk in Georgian Women: A Case-Control Study.
PG  - 11795549241233693
LID - 10.1177/11795549241233693 [doi]
LID - 11795549241233693
AB  - BACKGROUND: The folate metabolism pathway plays an integral part in DNA 
      synthesis, methylation, and repair. Methylenetetrahydrofolate reductase (MTHFR) 
      and methylenetetrahydrofolate dehydrogenase (MTHFD1) are both enzymes that are 
      involved in this pathway, and the single nucleotide polymorphisms (SNPs) in genes 
      coding for them have modulatory effects on DNA expression. This study aimed to 
      investigate the relationship between MTHFR C677T (rs1801133) and MTHFD1 G1958A 
      (rs2236225) polymorphisms and the risk of developing breast cancer in Georgian 
      women. METHODS: A case-control study was performed examining the MTHFR C677T and 
      MTHFD1 G1958A SNP in breast cancer-confirmed cases and healthy matched controls. 
      Real time-polymerase chain reaction (PCR) was used to genotype SNPs. The case 
      individuals' pathology reports were obtained following surgeries for cancer 
      characteristic data. Statistical analysis was performed to investigate the 
      significance of the acquired data. RESULTS: Statistical analysis of MTHFR C677T 
      SNP revealed that the CT genotype increased the risk of breast cancer by 2.17 
      folds in the over-dominant model. Statistical analysis of MTHFD1 G1958A SNP 
      showed that the GA genotype increased the risk of breast cancer by 4.12 folds in 
      the codominant model and 2.41 folds in the over-dominant model. No statistically 
      significant link was found between genotypes and lymph node status, however, 
      patients with the CT genotype had higher percentages of proliferative activity. 
      CONCLUSIONS: Breast cancer seems to have a statistically significant association 
      with the CT genotype in MTHFR C677T and the GA genotype in MTHFD1 G1958A in 
      Georgian women.
CI  - (c) The Author(s) 2024.
FAU - Ahmadi, Saba
AU  - Ahmadi S
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
FAU - Surmava, Sandro
AU  - Surmava S
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
FAU - Kvaratskhelia, Davit
AU  - Kvaratskhelia D
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
FAU - Gogolashvili, Ana
AU  - Gogolashvili A
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
FAU - Kvaratskhelia, Eka
AU  - Kvaratskhelia E
AUID- ORCID: 0000-0002-1200-0230
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
AD  - V. Bakhutashvili Institute of Medical Biotechnology, Tbilisi State Medical 
      University, Tbilisi, Georgia.
FAU - Abzianidze, Elene
AU  - Abzianidze E
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
AD  - Ivane Beritashvili Center Of Experimental Biomedicine, Tbilisi, Georgia.
FAU - Kankava, Ketevani
AU  - Kankava K
AD  - Department of Molecular and Medical Genetics, Tbilisi State Medical University, 
      Tbilisi, Georgia.
LA  - eng
PT  - Journal Article
DEP - 20240229
PL  - United States
TA  - Clin Med Insights Oncol
JT  - Clinical Medicine Insights. Oncology
JID - 101525771
PMC - PMC10908228
OTO - NOTNLM
OT  - MTHFD1
OT  - MTHFR
OT  - RT-PCR
OT  - breast cancer
OT  - proliferative activity
OT  - single nucleotide polymorphism
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2024/03/04 06:46
MHDA- 2024/03/04 06:47
PMCR- 2024/02/29
CRDT- 2024/03/04 04:36
PHST- 2023/07/24 00:00 [received]
PHST- 2024/02/01 00:00 [accepted]
PHST- 2024/03/04 06:47 [medline]
PHST- 2024/03/04 06:46 [pubmed]
PHST- 2024/03/04 04:36 [entrez]
PHST- 2024/02/29 00:00 [pmc-release]
AID - 10.1177_11795549241233693 [pii]
AID - 10.1177/11795549241233693 [doi]
PST - epublish
SO  - Clin Med Insights Oncol. 2024 Feb 29;18:11795549241233693. doi: 
      10.1177/11795549241233693. eCollection 2024.