PMID- 38434152
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 2211-8179 (Electronic)
IS  - 2211-8160 (Print)
IS  - 2211-8160 (Linking)
VI  - 19
IP  - 1
DP  - 2024
TI  - Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian 
      Cohort: MOYO Study.
PG  - 26
LID - 10.5334/gh.1298 [doi]
LID - 26
AB  - BACKGROUND: Non-ischemic dilated cardiomyopathy (NIDCM) is a common cause of 
      heart failure with progressive tendency. The disease occurs in one in every 2,500 
      individuals in the developed world, with high morbidity and mortality. However, 
      detailed data on the role of NIDCM in heart failure in Tanzania is lacking. AIM: 
      To characterize NIDCM in a Tanzanian cohort with respect to demographics, 
      clinical profile, imaging findings and management. METHODS: Characterization of 
      non-ischemic dilated cardioMyOpathY in a native Tanzanian cOhort (MOYO) is a 
      prospective cohort study of NIDCM patients seen at the Jakaya Kikwete Cardiac 
      Institute. Patients aged >/=18 years with a clinical diagnosis of heart failure, an 
      ejection fraction of </=45% on echocardiography and no evidence of ischemia were 
      enrolled. Clinical data, echocardiography, electrocardiography (ECG), coronary 
      angiography and stress ECG information were collected from February 2020 to March 
      2022. RESULTS: Of 402 patients, n = 220 (54.7%) were males with a median (IQR) 
      age of 55.0 (41.0, 66.0) years. Causes of NIDCM were presumably hypertensive n = 
      218 (54.2%), idiopathic n = 116 (28.9%), PPCM n = 45 (11.2%), alcoholic n = 10 
      (2.5%) and other causes n = 13 (3.2%). The most common presenting symptoms were 
      dyspnea n = 342 (85.1%), with the majority of patients presenting with New York 
      Heart Association (NYHA) Class III n = 195 (48.5%). The mean (SD) left 
      ventricular ejection fraction (LVEF) was 29.4% (+/-7.7), and severe systolic 
      dysfunction (LVEF <30%) was common n = 208 (51.7%). Compared with other forms of 
      DCM, idiopathic DCM patients were significantly younger, had more advanced NYHA 
      class (p < 0.001) and presented more often with left bundle branch block on ECG 
      (p = 0.0042). There was suboptimal use of novel guidelines recommended 
      medications ARNI n = 10 (2.5%) and SGLT2 2-inhibitors n = 2 (0.5%). CONCLUSIONS: 
      In our Tanzanian cohort, the majority of patients with NIDCM have an identified 
      underlying cause, and they present at late stages of the disease. Patients with 
      idiopathic DCM are younger with more severe disease compared to other forms of 
      NIDCM.
CI  - Copyright: (c) 2024 The Author(s).
FAU - Fundikira, Lulu Said
AU  - Fundikira LS
AUID- ORCID: 0000-0002-4953-7699
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, United 
      Republic of Tanzania, Tanzania.
FAU - Chillo, Pilly
AU  - Chillo P
AUID- ORCID: 0000-0001-7073-1122
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, United 
      Republic of Tanzania, Tanzania.
AD  - Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania.
FAU - Alimohamed, Mohamed Z
AU  - Alimohamed MZ
AUID- ORCID: 0000-0002-1240-928X
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, United 
      Republic of Tanzania, Tanzania.
AD  - Tanzania Human Genetics Organization, Dar es Salaam, Tanzania.
FAU - Mayala, Henry
AU  - Mayala H
AUID- ORCID: 0000-0001-9677-2520
AD  - Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania.
FAU - Kifai, Engerasiya
AU  - Kifai E
AUID- ORCID: 0000-0001-6089-9087
AD  - Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania.
FAU - Aloyce, Geofrey M
AU  - Aloyce GM
AUID- ORCID: 0009-0005-0517-0222
AD  - Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania.
FAU - Kamuhabwa, Appolinary
AU  - Kamuhabwa A
AUID- ORCID: 0000-0001-6895-9187
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, United 
      Republic of Tanzania, Tanzania.
FAU - Kwesigabo, Gideon
AU  - Kwesigabo G
AUID- ORCID: 0000-0003-3302-6736
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, United 
      Republic of Tanzania, Tanzania.
FAU - van Laake, Linda W
AU  - van Laake LW
AUID- ORCID: 0000-0002-5027-0661
AD  - Department of Cardiology, Division of Heart and Lungs, University Medical Centre 
      Utrecht, Utrecht University, Utrecht, The Netherlands.
FAU - Asselbergs, Folkert W
AU  - Asselbergs FW
AUID- ORCID: 0000-0002-1692-8669
AD  - Amsterdam University Medical Centers, Department of Cardiology, University of 
      Amsterdam, Amsterdam, The Netherlands.
AD  - Health Data Research UK and Institute of Health Informatics, University College 
      London, London, United Kingdom.
AD  - The National Institute for Health Research University College London Hospitals 
      Biomedical Research Centre, University College London, London, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20240229
PL  - England
TA  - Glob Heart
JT  - Global heart
JID - 101584391
SB  - IM
MH  - Male
MH  - Humans
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Tanzania/epidemiology
MH  - *Cardiomyopathy, Dilated/diagnosis/epidemiology
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - *Heart Failure/diagnosis/epidemiology/etiology
PMC - PMC10906337
OTO - NOTNLM
OT  - echocardiography
OT  - heart failure
OT  - non-ischemic dilated cardiomyopathy
COIS- FA received grant funding from the EU Horizon scheme (AI4HF 101080430 and 
      DataTools4Heart 101057849). Other authors declare no competing interest.
EDAT- 2024/03/04 06:47
MHDA- 2024/03/05 06:47
PMCR- 2024/02/29
CRDT- 2024/03/04 04:41
PHST- 2023/10/09 00:00 [received]
PHST- 2024/01/12 00:00 [accepted]
PHST- 2024/03/05 06:47 [medline]
PHST- 2024/03/04 06:47 [pubmed]
PHST- 2024/03/04 04:41 [entrez]
PHST- 2024/02/29 00:00 [pmc-release]
AID - 10.5334/gh.1298 [doi]
PST - epublish
SO  - Glob Heart. 2024 Feb 29;19(1):26. doi: 10.5334/gh.1298. eCollection 2024.