PMID- 38435199 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240305 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 2 DP - 2024 Feb TI - Overlap Syndrome of Immune Reconstitution Inflammatory Syndrome Secondary to Disseminated Mycobacterial Infection and Hemophagocytic Lymphohistiocytosis in a Patient With Newly Diagnosed HIV/AIDS. PG - e53410 LID - 10.7759/cureus.53410 [doi] LID - e53410 AB - Immune reconstitution inflammatory syndrome (IRIS) following initiation of antiretroviral therapy (ART) has variable incidence but is not uncommon and has the potential to cause long-term consequences and fatal outcomes in patients with HIV. Hemophagocytic lymphohistiocytosis (HLH) is a separate syndrome of excess immune activation, but may coexist with IRIS and necessitate a unique treatment approach. In this report, the case of a patient with newly diagnosed HIV/AIDS who was found to have both mycobacterial IRIS and HLH is presented. CI - Copyright (c) 2024, Patel et al. FAU - Patel, Nishant AU - Patel N AD - Infectious Diseases, Vanderbilt University Medical Center, Nashville, USA. FAU - Chastain, Cody AU - Chastain C AD - Infectious Diseases, Vanderbilt University Medical Center, Nashville, USA. LA - eng PT - Case Reports DEP - 20240201 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC10908438 OTO - NOTNLM OT - acquired immune deficiency syndrome OT - aids OT - antiretroviral therapy OT - hiv OT - hlh OT - human immunodeficiency virus OT - iris OT - mycobacteria COIS- The authors have declared that no competing interests exist. EDAT- 2024/03/04 06:48 MHDA- 2024/03/04 06:49 PMCR- 2024/02/01 CRDT- 2024/03/04 04:57 PHST- 2024/02/01 00:00 [accepted] PHST- 2024/03/04 06:49 [medline] PHST- 2024/03/04 06:48 [pubmed] PHST- 2024/03/04 04:57 [entrez] PHST- 2024/02/01 00:00 [pmc-release] AID - 10.7759/cureus.53410 [doi] PST - epublish SO - Cureus. 2024 Feb 1;16(2):e53410. doi: 10.7759/cureus.53410. eCollection 2024 Feb.