PMID- 38435385
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240305
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 11
DP  - 2024
TI  - Characteristic cytokine profile of the aqueous humor in eyes with congenital 
      cataract and pre-existing posterior capsule dysfunction.
PG  - 1301588
LID - 10.3389/fmed.2024.1301588 [doi]
LID - 1301588
AB  - OBJECTIVES: To investigate the characteristic cytokine profile of the aqueous 
      humor in eyes with congenital cataract and pre-existing posterior capsule 
      dysfunction (PCD). METHODS: In this cross-sectional study, the enrolled eyes with 
      congenital cataract and PCD were included in the PCD group, while those with an 
      intact posterior capsule were included in the control group. Demographic data and 
      biometric parameters were recorded. The levels of 17 inflammatory factors in the 
      aqueous humor collected from the enrolled eyes were detected using Luminex xMAP 
      technology, and intergroup differences in the collected data were analyzed. 
      RESULTS: The PCD group comprised 41 eyes from 31 patients with congenital 
      cataract and PCD, whereas the control group comprised 42 eyes from 27 patients 
      with congenital cataract and an intact posterior capsule. Lens thickness was 
      significantly thinner in the PCD group than in the control group. However, the 
      levels of monocyte chemoattractant protein-1 (MCP-1), transforming growth 
      factor-beta2 (TGF-beta2), and vascular endothelial growth factor (VEGF) were 
      significantly higher in the PCD group than in the control group. Multivariate 
      logistic regression confirmed that lens thickness and TGF-beta2 level were 
      independent risk factors for PCD. CONCLUSION: A thinner lens thickness in eyes 
      with congenital cataract and PCD could serve as a biometric feature of these 
      eyes. The higher levels of MCP-1, TGF-beta2, and VEGF in eyes with PCD indicated a 
      change in their intraocular inflammatory microenvironment, which possibly led to 
      cataract progression. Lens thickness and TGF-beta2 level are independent risk 
      factors for PCD.
CI  - Copyright (c) 2024 Zhao, Zhao, Zhang, Zhang, Wang, Li, Ding and Zhao.
FAU - Zhao, Yinying
AU  - Zhao Y
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Zhao, Qihui
AU  - Zhao Q
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Zhang, Hongfang
AU  - Zhang H
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Zhang, Zhewen
AU  - Zhang Z
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Wang, Dandan
AU  - Wang D
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Li, Zhangliang
AU  - Li Z
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Ding, Xixia
AU  - Ding X
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
FAU - Zhao, Yune
AU  - Zhao Y
AD  - The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
AD  - National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20240216
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10904641
OTO - NOTNLM
OT  - aqueous humor
OT  - congenital cataract
OT  - cytokine profile
OT  - inflammatory factors
OT  - posterior capsule dysfunction
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/04 06:43
MHDA- 2024/03/04 06:44
PMCR- 2024/02/16
CRDT- 2024/03/04 04:59
PHST- 2023/09/25 00:00 [received]
PHST- 2024/02/05 00:00 [accepted]
PHST- 2024/03/04 06:44 [medline]
PHST- 2024/03/04 06:43 [pubmed]
PHST- 2024/03/04 04:59 [entrez]
PHST- 2024/02/16 00:00 [pmc-release]
AID - 10.3389/fmed.2024.1301588 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2024 Feb 16;11:1301588. doi: 10.3389/fmed.2024.1301588. 
      eCollection 2024.