PMID- 38435634
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240305
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 17
DP  - 2024
TI  - Gender Differences in the Incidence of Nephropathy and Changes in Renal Function 
      in Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study.
PG  - 943-957
LID - 10.2147/DMSO.S451628 [doi]
AB  - PURPOSE: This research aims to examine and scrutinize gender variations in the 
      incidence of diabetic nephropathy (DN) and the trajectory of renal function in 
      type 2 diabetes mellitus (T2DM) patients. PATIENTS AND METHODS: We conducted a 
      retrospective cohort study that enrolled 1549 patients diagnosed with T2DM from 
      May 2015 to July 2023. We separately compared the clinical characteristics of 
      male and female participants with and without DN. We utilized the Kaplan-Meier 
      method to examine the cumulative incidence of DN among T2DM patients of varying 
      genders. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated 
      using univariable and multivariable Cox proportional hazards regression analysis 
      to evaluate the correlation between various factors and the risk of DN incidence. 
      Multiple linear regression was utilized to investigate the relationship between 
      DeltaeGFR% and each factor. Logistic regression with cubic spline function and smooth 
      curve fitting was employed to analyze the nonlinear link between DeltaeGFR% and the 
      risk of DN among participants of different genders. RESULTS: The prevalence of DN 
      was higher in female participants (17.31%) than in male participants (12.62%), 
      with a significant cumulative risk ratio (1.33 [1.02-1.73], P = 0.034). Multiple 
      linear regression analysis revealed that creatinine, female gender, blood urea 
      nitrogen, alkaline phosphatase, and total cholesterol had a significant impact on 
      DeltaeGFR% in T2DM patients, with standardized beta coefficients of -0.325, -0.219, 
      -0.164, -0.084, and 0.071, respectively. The restricted cubic spline analysis 
      demonstrated a strong negative association between DeltaeGFR% and the risk of 
      developing DN (P < 0.001). CONCLUSION: Both male and female patients with T2DM 
      had a higher prevalence of DN over the 5-year follow-up period. However, women 
      had a greater risk of developing DN and a faster decline in renal function 
      compared to men.
CI  - (c) 2024 Zhang et al.
FAU - Zhang, Fan
AU  - Zhang F
AUID- ORCID: 0000-0001-9028-6185
AD  - Department of Endocrinology, Changzhou Third People's Hospital, Changzhou Medical 
      Center, Nanjing Medical University, Changzhou, Jiangsu, People's Republic of 
      China.
AD  - Department of Clinical Nutrition, Changzhou Third People's Hospital, Changzhou 
      Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People's Republic 
      of China.
FAU - Han, Yan
AU  - Han Y
AD  - Department of Endocrinology, Changzhou Third People's Hospital, Changzhou Medical 
      Center, Nanjing Medical University, Changzhou, Jiangsu, People's Republic of 
      China.
AD  - Department of Clinical Nutrition, Changzhou Third People's Hospital, Changzhou 
      Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People's Republic 
      of China.
FAU - Zheng, Guojun
AU  - Zheng G
AD  - Clinical Laboratory, Changzhou Third People's Hospital, Changzhou Medical Center, 
      Nanjing Medical University, Changzhou, Jiangsu, People's Republic of China.
FAU - Li, Wenjian
AU  - Li W
AUID- ORCID: 0000-0002-7650-8842
AD  - Department of Urology, Changzhou Third People's Hospital, Changzhou Medical 
      Center, Nanjing Medical University, Changzhou, Jiangsu, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240226
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10906732
OTO - NOTNLM
OT  - gender differences
OT  - glomerular filtration rate estimates
OT  - nephropathy
OT  - renal function
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest in this study.
EDAT- 2024/03/04 06:48
MHDA- 2024/03/04 06:49
PMCR- 2024/02/26
CRDT- 2024/03/04 05:03
PHST- 2023/12/05 00:00 [received]
PHST- 2024/02/19 00:00 [accepted]
PHST- 2024/03/04 06:49 [medline]
PHST- 2024/03/04 06:48 [pubmed]
PHST- 2024/03/04 05:03 [entrez]
PHST- 2024/02/26 00:00 [pmc-release]
AID - 451628 [pii]
AID - 10.2147/DMSO.S451628 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2024 Feb 26;17:943-957. doi: 10.2147/DMSO.S451628. 
      eCollection 2024.