PMID- 38436389
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 1537-1603 (Electronic)
IS  - 0736-0258 (Linking)
VI  - 41
IP  - 3
DP  - 2024 Mar 1
TI  - Nonconvulsive Status Epilepticus: Clinical Findings, EEG Features, and Prognosis 
      in a Developing Country, Mexico.
PG  - 221-229
LID - 10.1097/WNP.0000000000000953 [doi]
AB  - PURPOSE: There is a lack of clinical and epidemiological knowledge about 
      nonconvulsive status epilepticus (NCSE) in developing countries including Mexico, 
      which has the highest prevalence of epilepsy in the Americas. Our aim was to 
      describe the clinical findings, EEG features, and outcomes of NCSE in a tertiary 
      center in Mexico. METHODS: We conducted a retrospective case series study 
      (2010-2020) including patients (>/=15 years old) with NCSE according to the 
      modified Salzburg NCSE criteria 2015 with at least 6 months of follow-up. We 
      extracted the clinical data (age, sex, history of epilepsy, antiseizure 
      medications, clinical manifestations, triggers, and etiology), EEG patterns of 
      NCSE, and outcome. Descriptive statistics and multinomial logistic regression 
      were used. RESULTS: One hundred thirty-four patients were analyzed; 74 (54.8%) 
      women, the total mean age was 39.5 (15-85) years, and 71% had a history of 
      epilepsy. Altered state of consciousness was found in 82% (including 27.7% in 
      coma). A generalized NCSE pattern was the most common (32.1%). The NCSE etiology 
      was mainly idiopathic (56%), and previous uncontrolled epilepsy was the trigger 
      in 48% of patients. The clinical outcome was remission with clinical improvement 
      in 54.5%. Multinomial logistic regression showed that the patient's age (P = 
      0.04), absence of comorbidities (P = 0.04), history of perinatal hypoxia (P = 
      0.04), absence of clinical manifestations (P = 0.01), and coma (P = 0.03) were 
      negatively correlated with the outcome and only the absence of generalized 
      slowing in the EEG (P = 0.001) had a significant positive effect on the 
      prognosis. CONCLUSIONS: Age, history of perinatal hypoxia, coma, and focal ictal 
      EEG pattern influence negatively the prognosis of NCSE.
CI  - Copyright (c) 2022 by the American Clinical Neurophysiology Society.
FAU - San-Juan, Daniel
AU  - San-Juan D
AD  - Epilepsy Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco 
      Suarez, Mexico City, Mexico.
FAU - Angeles, Erick B
AU  - Angeles EB
AD  - Clinical Neurophysiology Department, National Institute of Neurology and 
      Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.
FAU - Gonzalez-Aragon, Maria Del Carmen F
AU  - Gonzalez-Aragon MDCF
AD  - Clinical Neurophysiology Department, National Institute of Neurology and 
      Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.
FAU - Torres, Jacob Eli G
AU  - Torres JEG
AD  - Epilepsy Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco 
      Suarez, Mexico City, Mexico.
FAU - Lorenzana, Angel L
AU  - Lorenzana AL
AD  - Epilepsy Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco 
      Suarez, Mexico City, Mexico.
FAU - Trenado, Carlos
AU  - Trenado C
AD  - Dusseldorf and Systems Neuroscience and Neurotechnology Unit, Faculty of 
      Medicine, Institute of Clinical Neuroscience and Medical Psychology, Medical 
      Faculty, Heinrich-Heine-University, Saarland University and HTW Saarland, 
      Homburg, Germany; and.
FAU - Anschel, David J
AU  - Anschel DJ
AD  - St. Charles Epilepsy, New York University Comprehensive Epilepsy Center, St. 
      Charles Hospital, Port Jefferson, New York, U.S.A.
LA  - eng
PT  - Journal Article
DEP - 20220701
PL  - United States
TA  - J Clin Neurophysiol
JT  - Journal of clinical neurophysiology : official publication of the American 
      Electroencephalographic Society
JID - 8506708
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - Adult
MH  - Adolescent
MH  - Male
MH  - Mexico/epidemiology
MH  - Coma
MH  - Developing Countries
MH  - Retrospective Studies
MH  - *Status Epilepticus/diagnosis/epidemiology/therapy
MH  - Prognosis
MH  - Hypoxia
MH  - *Epilepsy
MH  - Electroencephalography
COIS- The authors have no funding or conflicts of interest to disclose.
EDAT- 2024/03/04 12:46
MHDA- 2024/03/05 06:46
CRDT- 2024/03/04 09:55
PHST- 2024/03/05 06:46 [medline]
PHST- 2024/03/04 12:46 [pubmed]
PHST- 2024/03/04 09:55 [entrez]
AID - 00004691-202403000-00006 [pii]
AID - 10.1097/WNP.0000000000000953 [doi]
PST - ppublish
SO  - J Clin Neurophysiol. 2024 Mar 1;41(3):221-229. doi: 10.1097/WNP.0000000000000953. 
      Epub 2022 Jul 1.