PMID- 38436476
OWN - NLM
STAT- MEDLINE
DCOM- 20240419
LR  - 20240425
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 79
IP  - 5
DP  - 2024 May 1
TI  - The Impact of Type 2 Diabetes on Peripheral and Cerebral Hemodynamic Responses to 
      Active Stand.
LID - 10.1093/gerona/glae073 [doi]
LID - glae073
AB  - BACKGROUND: Although type 2 diabetes mellitus (T2DM) is an established risk 
      factor for cognitive impairment, the underlying mechanisms remain poorly 
      explored. One potential mechanism may be through effects of T2DM on cerebral 
      perfusion. The current study hypothesized that T2DM is associated with altered 
      peripheral and central hemodynamic responses to orthostasis, which may in turn be 
      associated with cognitive impairment in T2DM. METHODS: A novel use of 
      function-on-scalar regression, which allows the entire hemodynamic response curve 
      to be modeled, was employed to assess the association between T2DM and 
      hemodynamic responses to orthostasis. Logistic regression was used to assess the 
      relationship between tissue saturation index (TSI), T2DM, and cognitive 
      impairment. All analyses used cross-sectional data from Wave 3 of The Irish 
      Longitudinal Study on Ageing (TILDA). RESULTS: Of 2 984 older adults (aged 
      64.3 +/- 8.0; 55% female), 189 (6.3%) had T2DM. T2DM was associated with many 
      features that are indicative of autonomic dysfunction including a blunted peak 
      heart rate and lower diastolic blood pressure. T2DM was associated with reduced 
      TSI and also with greater odds of impaired performance on the Montreal Cognitive 
      Assessment (odds ratio [OR]: 1.62; confidence interval [CI: 1.07, 2.56]; 
      p = .019). Greater TSI was associated with lower odds of impaired performance 
      (OR: 0.90, CI [0.81-0.99]; p = .047). CONCLUSIONS: T2DM was associated with 
      impaired peripheral and cerebral hemodynamic responses to active stand. Both T2DM 
      and reduced cerebral perfusion were associated with impaired cognitive 
      performance. Altered cerebral perfusion may represent an important mechanism 
      linking T2DM and adverse brain health outcomes in older adults.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of The 
      Gerontological Society of America.
FAU - Hernandez, Belinda
AU  - Hernandez B
AUID- ORCID: 0000-0001-5034-1282
AD  - The Irish Longitudinal Study on Ageing, Department of Medical Gerontology, School 
      of Medicine, Trinity College Dublin, Dublin, Ireland.
AD  - Discipline of Medical Gerontology, School of Medicine, Trinity College, Dublin, 
      Ireland.
FAU - Dyer, Adam H
AU  - Dyer AH
AUID- ORCID: 0000-0003-1356-510X
AD  - Discipline of Medical Gerontology, School of Medicine, Trinity College, Dublin, 
      Ireland.
AD  - Department of Age-Related Healthcare, Tallaght University Hospital, Dublin, 
      Ireland.
FAU - Finucane, Ciaran
AU  - Finucane C
AD  - Discipline of Medical Gerontology, School of Medicine, Trinity College, Dublin, 
      Ireland.
AD  - Mercer's Institute for Successful Ageing, St. James's Hospital, Trinity College, 
      The University of Dublin, Dublin, Ireland.
FAU - Nipoti, Bernardo
AU  - Nipoti B
AD  - Department of Economics, Management, and Statistics, University of 
      Milano-Bicocca, Milan, Italy.
FAU - Romero-Ortuno, Roman
AU  - Romero-Ortuno R
AUID- ORCID: 0000-0002-3882-7447
AD  - Discipline of Medical Gerontology, School of Medicine, Trinity College, Dublin, 
      Ireland.
AD  - Mercer's Institute for Successful Ageing, St. James's Hospital, Trinity College, 
      The University of Dublin, Dublin, Ireland.
FAU - Reilly, Richard
AU  - Reilly R
AUID- ORCID: 0000-0001-8578-1245
AD  - School of Engineering, Trinity College, The University of Dublin, Dublin, 
      Ireland.
AD  - Trinity Centre for Biomedical Engineering, Trinity College, The University of 
      Dublin, Dublin, Ireland.
FAU - Kenny, Rose Anne
AU  - Kenny RA
AD  - The Irish Longitudinal Study on Ageing, Department of Medical Gerontology, School 
      of Medicine, Trinity College Dublin, Dublin, Ireland.
AD  - Discipline of Medical Gerontology, School of Medicine, Trinity College, Dublin, 
      Ireland.
LA  - eng
GR  - 18/FRL/6188/SFI_/Science Foundation Ireland/Ireland
GR  - HRBI_/Health Research Board/Ireland
GR  - 203930/B/16/Z/HRBI_/Health Research Board/Ireland
GR  - ILP-HSR-2017-021/HRBI_/Health Research Board/Ireland
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - Humans
MH  - Female
MH  - Aged
MH  - Male
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Longitudinal Studies
MH  - Dizziness
MH  - Cross-Sectional Studies
MH  - *Cognitive Dysfunction/etiology
MH  - Hemodynamics
PMC - PMC11025558
OTO - NOTNLM
OT  - Active stand
OT  - Cerebral perfusion
OT  - Functional regression
OT  - Orthostasis
OT  - Type 2 diabetes
COIS- None.
EDAT- 2024/03/04 12:45
MHDA- 2024/04/19 06:43
PMCR- 2024/03/04
CRDT- 2024/03/04 10:00
PHST- 2023/09/20 00:00 [received]
PHST- 2024/04/19 06:43 [medline]
PHST- 2024/03/04 12:45 [pubmed]
PHST- 2024/03/04 10:00 [entrez]
PHST- 2024/03/04 00:00 [pmc-release]
AID - 7618536 [pii]
AID - glae073 [pii]
AID - 10.1093/gerona/glae073 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2024 May 1;79(5):glae073. doi: 
      10.1093/gerona/glae073.