PMID- 38438022
OWN - NLM
STAT- Publisher
LR  - 20240304
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
DP  - 2024 Mar 2
TI  - Combined association of urinary volatile organic compounds with chronic 
      bronchitis and emphysema among adults in NHANES 2011-2014: The mediating role of 
      inflammation.
PG  - 141485
LID - S0045-6535(24)00378-3 [pii]
LID - 10.1016/j.chemosphere.2024.141485 [doi]
AB  - Evidence on the association of volatile organic compounds (VOCs) with chronic 
      bronchitis (CB) and emphysema is spare and defective. To evaluate the 
      relationship between urinary metabolites of VOCs (mVOCs) with CB and emphysema, 
      and to identify the potential mVOC of paramount importance, data from NHANES 
      2011-2014 waves were utilized. Logistic regression was conducted to estimate the 
      independent association of mVOCs with respiratory outcomes. Least absolute 
      shrinkage and selection operator (LASSO) regression was performed to screen a 
      parsimonious set of CB- and emphysema-relevant mVOCs that were used for further 
      co-exposure analyses of weight quantile sum (WQS) regression and Bayesian kernel 
      machine regression (BKMR). Mediation analysis was employed to detect the 
      mediating role of inflammatory makers in such associations. In single exposure 
      analytic model, nine mVOCs were individually and positively associated with CB, 
      while four mVOCs were with emphysema. In WQS regression, positive association 
      between LASSO selected mVOCs and CB was identified (OR = 1.82, 95% CI: 1.25 to 
      2.69), and N-acetyl-S-(4-hydroxy-2-butenyl)-l-cysteine (MHBMA3) weighted the 
      highest. Results from BKMR further validated such combined association and the 
      significance of MHBMA3. As for emphysema, significantly positive overall trend of 
      mVOCs was only observed in BKMR model and 
      N-acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC) contributed most to the mixed 
      effect. White blood cell count (WBC) and lymphocyte number (LYM) were mediators 
      in the positive pattern of mVOCs mixture with CB, while association between mVOCs 
      mixture and emphysema was significantly mediated by LYM and segmented neutrophils 
      num (NEO). This study demonstrated that exposure to VOCs was associated with CB 
      and emphysema independently and combinedly, which might be partly speculated that 
      VOCs were linked to activated inflammations. Our findings shed novel light on 
      VOCs related respiratory illness, and provide a new basis for the contribution of 
      certain VOCs to the risk of CB and emphysema, which has potential public health 
      implications.
CI  - Copyright (c) 2024. Published by Elsevier Ltd.
FAU - Wang, Yucheng
AU  - Wang Y
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China.
FAU - Yu, Yongquan
AU  - Yu Y
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China.
FAU - Zhang, Xiaoxuan
AU  - Zhang X
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China.
FAU - Zhang, Hu
AU  - Zhang H
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China.
FAU - Wang, Shizhi
AU  - Wang S
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China.
FAU - Yin, Lihong
AU  - Yin L
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, China. Electronic 
      address: lhyin@seu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240302
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
SB  - IM
OTO - NOTNLM
OT  - Chronic bronchitis
OT  - Emphysema
OT  - Mediation
OT  - Mixed exposure
OT  - Volatile organic compounds
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/05 00:45
MHDA- 2024/03/05 00:45
CRDT- 2024/03/04 19:14
PHST- 2023/05/10 00:00 [received]
PHST- 2024/01/26 00:00 [revised]
PHST- 2024/02/15 00:00 [accepted]
PHST- 2024/03/05 00:45 [medline]
PHST- 2024/03/05 00:45 [pubmed]
PHST- 2024/03/04 19:14 [entrez]
AID - S0045-6535(24)00378-3 [pii]
AID - 10.1016/j.chemosphere.2024.141485 [doi]
PST - aheadofprint
SO  - Chemosphere. 2024 Mar 2:141485. doi: 10.1016/j.chemosphere.2024.141485.