PMID- 38438641
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 31
IP  - 16
DP  - 2024 Apr
TI  - Combined exposure to multiple metals on abdominal aortic calcification: results 
      from the NHANES study.
PG  - 24282-24301
LID - 10.1007/s11356-024-32745-9 [doi]
AB  - Exposure to metals increases the risk of many diseases and has become a public 
      health concern. However, few studies have focused on the effect of metal on 
      abdominal aortic calcification (AAC), especially the combined effects of metal 
      mixtures. In this study, we aim to investigate the combined effect of metals on 
      AAC risk and determine the key components in the multiple metals. We tried to 
      investigate the relationship between multiple metal exposure and AAC risk. 
      Fourteen urinary metals were analyzed with five statistical models as follows: 
      generalized linear regression, weighted quantile sum regression (WQS), quantile 
      g-computation (Qgcomp), and Bayesian kernel machine regression (BKMR) models. A 
      total of 838 participants were involved, of whom 241 (28.8%) had AAC. After 
      adjusting for covariates, in multiple metal exposure logistic regression, cadmium 
      (Cd) (OR = 1.364, 95% CI = 1.035-1.797) was positively associated with AAC risk, 
      while cobalt (Co) (OR = 0.631, 95% CI = 0.438-0.908) was negatively associated 
      with AAC risk. A significant positive effect between multiple metal exposure and 
      AAC risk was observed in WQS (OR = 2.090; 95% CI = 1.280-3.420, P < 0.01), Qgcomp 
      (OR = 1.522, 95% CI = 1.012-2.290, P < 0.05), and BKMR models. It was found that 
      the positive association may be driven primarily by Cd, lead (Pb), uranium (U), 
      and tungsten (W). Subgroups analysis showed the association was more significant 
      in participants with BMI >/= 25 kg/m(2), abdominal obesity, drinking, and smoking. 
      Our study shows that exposure to multiple metals increases the risk of AAC in 
      adults aged >/= 40 years in the USA and that Cd, Pb, U, and W are the main 
      contributors. The association is stronger in participants who are obese, smoker, 
      or drinker.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhou, Yuan-Hang
AU  - Zhou YH
AD  - Department of Cardiology, Cardiovascular Center, First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, 450052, China.
AD  - Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou, 450052, 
      China.
FAU - Bai, Yu-Jie
AU  - Bai YJ
AD  - Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, 450052, China.
FAU - Zhao, Xiao-Yan
AU  - Zhao XY
AD  - Department of Cardiology, Cardiovascular Center, First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, 450052, China. zz_zdyfyheart@163.com.
AD  - Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou, 450052, 
      China. zz_zdyfyheart@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240304
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - 3G0H8C9362 (Cobalt)
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Cadmium
MH  - Bayes Theorem
MH  - Lead
MH  - Nutrition Surveys
MH  - Cobalt
MH  - Obesity
MH  - *Metals, Heavy
OTO - NOTNLM
OT  - Abdominal aortic calcification
OT  - BKMR
OT  - Metal
OT  - Qgcomp
OT  - WQS
EDAT- 2024/03/05 00:45
MHDA- 2024/04/08 06:43
CRDT- 2024/03/04 23:33
PHST- 2023/10/11 00:00 [received]
PHST- 2024/02/28 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/03/05 00:45 [pubmed]
PHST- 2024/03/04 23:33 [entrez]
AID - 10.1007/s11356-024-32745-9 [pii]
AID - 10.1007/s11356-024-32745-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2024 Apr;31(16):24282-24301. doi: 
      10.1007/s11356-024-32745-9. Epub 2024 Mar 4.