PMID- 38438820
OWN - NLM
STAT- Publisher
LR  - 20240304
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
DP  - 2024 Mar 5
TI  - Quantitative whole-body muscle MRI in idiopathic inflammatory myopathies 
      including polymyositis with mitochondrial pathology: indications for a disease 
      spectrum.
LID - 10.1007/s00415-024-12191-w [doi]
AB  - OBJECTIVE: Inflammatory myopathies (IIM) include dermatomyositis (DM), sporadic 
      inclusion body myositis (sIBM), immune-mediated necrotizing myopathy (IMNM), and 
      overlap myositis (OLM)/antisynthetase syndrome (ASyS). There is also a rare 
      variant termed polymyositis with mitochondrial pathology (PM-Mito), which is 
      considered a sIBM precursor. There is no information regarding muscle MRI for 
      this rare entity. The aim of this study was to compare MRI findings in IIM, 
      including PM-Mito. METHODS: This retrospective analysis included 41 patients (7 
      PM-Mito, 11 sIBM, 11 PM/ASyS/OLM, 12 IMNM) and 20 healthy controls. Pattern of 
      muscle involvement was assessed by semiquantitative evaluation, while Dixon 
      method was used to quantify muscular fat fraction. RESULTS: The sIBM typical 
      pattern affecting the lower extremities was not found in the majority of 
      PM-Mito-patients. Intramuscular edema in sIBM and PM-Mito was limited to the 
      lower extremities, whereas IMNM and PM/ASyS/OLM showed additional edema in the 
      trunk. Quantitative assessment showed increased fat content in sIBM, with an 
      intramuscular proximo-distal gradient. Similar changes were also found in a few 
      PM-Mito- and PM/ASyS/OLM patients. In sIBM and PM-Mito, mean fat fraction of 
      several muscles correlated with clinical involvement. INTERPRETATION: As MRI 
      findings in patients with PM-Mito relevantly differed from sIBM, the attribution 
      of PM-Mito as sIBM precursor should be critically discussed. Some patients in 
      PM/ASyS/OLM and PM-Mito group showed MR-morphologic features predominantly 
      observed in sIBM, indicative of a spectrum from PM/ASyS/OLM toward sIBM. In some 
      IIM subtypes, MRI may serve as a biomarker of disease severity.
CI  - (c) 2024. The Author(s).
FAU - Zierer, Lea-Katharina
AU  - Zierer LK
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
AD  - Department of Radiology, University Medicine Halle, Halle (Saale), Germany.
FAU - Naegel, Steffen
AU  - Naegel S
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
AD  - Department of Neurology, Alfried-Krupp-Krankenhaus Essen, Essen, Germany.
FAU - Schneider, Ilka
AU  - Schneider I
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
AD  - Department of Neurology, St. Georg Hospital Leipzig, Leipzig, Germany.
FAU - Kendzierski, Thomas
AU  - Kendzierski T
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
FAU - Kleeberg, Kathleen
AU  - Kleeberg K
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
FAU - Koelsch, Anna Katharina
AU  - Koelsch AK
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
FAU - Scholle, Leila
AU  - Scholle L
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
FAU - Schaefer, Christoph
AU  - Schaefer C
AD  - Department of Internal Medicine II, Rheumatology, University Medicine Halle, 
      Halle (Saale), Germany.
FAU - Naegel, Arne
AU  - Naegel A
AD  - Goethe Center for Scientific Computing (G-CSC), Goethe University, 
      Frankfurt/Main, Germany.
FAU - Zierz, Stephan
AU  - Zierz S
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
FAU - Otto, Markus
AU  - Otto M
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
FAU - Stoltenburg-Didinger, Gisela
AU  - Stoltenburg-Didinger G
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
AD  - Institute of Cell and Neurobiology, Charite University Medicine Berlin, Berlin, 
      Germany.
FAU - Kraya, Torsten
AU  - Kraya T
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany.
AD  - Department of Neurology, St. Georg Hospital Leipzig, Leipzig, Germany.
FAU - Stoevesandt, Dietrich
AU  - Stoevesandt D
AD  - Department of Radiology, University Medicine Halle, Halle (Saale), Germany.
FAU - Mensch, Alexander
AU  - Mensch A
AUID- ORCID: 0000-0003-0089-4473
AD  - Department of Neurology, University Medicine Halle, Ernst-Grube-Str. 40, 06120, 
      Halle (Saale), Germany. alexander.mensch@medizin.uni-halle.de.
LA  - eng
PT  - Journal Article
DEP - 20240305
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
OTO - NOTNLM
OT  - IBM
OT  - Imaging biomarker
OT  - Inclusion body myositis
OT  - Myositis
OT  - PM-Mito
OT  - qMRI
EDAT- 2024/03/05 00:45
MHDA- 2024/03/05 00:45
CRDT- 2024/03/04 23:40
PHST- 2023/09/03 00:00 [received]
PHST- 2024/01/04 00:00 [accepted]
PHST- 2024/01/01 00:00 [revised]
PHST- 2024/03/05 00:45 [medline]
PHST- 2024/03/05 00:45 [pubmed]
PHST- 2024/03/04 23:40 [entrez]
AID - 10.1007/s00415-024-12191-w [pii]
AID - 10.1007/s00415-024-12191-w [doi]
PST - aheadofprint
SO  - J Neurol. 2024 Mar 5. doi: 10.1007/s00415-024-12191-w.