PMID- 38438934
OWN - NLM
STAT- MEDLINE
DCOM- 20240306
LR  - 20240307
IS  - 2047-783X (Electronic)
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 29
IP  - 1
DP  - 2024 Mar 4
TI  - Advances in secondary prevention mechanisms of macrovascular complications in 
      type 2 diabetes mellitus patients: a comprehensive review.
PG  - 152
LID - 10.1186/s40001-024-01739-1 [doi]
LID - 152
AB  - Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is 
      particularly due to its macrovascular complications, such as coronary artery 
      disease, peripheral vascular disease, and cerebrovascular disease, which have 
      emerged as leading contributors to morbidity and mortality. This review 
      comprehensively explores the pathophysiological mechanisms underlying these 
      complications, protective strategies, and both existing and emerging secondary 
      preventive measures. Furthermore, we delve into the applications of experimental 
      models and methodologies in foundational research while also highlighting current 
      research limitations and future directions. Specifically, we focus on the 
      literature published post-2020 concerning the secondary prevention of 
      macrovascular complications in patients with T2DM by conducting a targeted review 
      of studies supported by robust evidence to offer a holistic perspective.
CI  - (c) 2024. The Author(s).
FAU - Guan, Huifang
AU  - Guan H
AD  - College of Traditional Chinese Medicine, Changchun University of Chinese 
      Medicine, Changchun, 130117, China.
FAU - Tian, Jiaxing
AU  - Tian J
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China. tina_yai@126.com.
FAU - Wang, Ying
AU  - Wang Y
AD  - College of Traditional Chinese Medicine, Changchun University of Chinese 
      Medicine, Changchun, 130117, China.
FAU - Niu, Ping
AU  - Niu P
AD  - Rehabilitation Department, The Affiliated Hospital of Changchun University of 
      Chinese Medicine, Changchun, 130021, China.
FAU - Zhang, Yuxin
AU  - Zhang Y
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China.
FAU - Zhang, Yanjiao
AU  - Zhang Y
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China.
FAU - Fang, Xinyi
AU  - Fang X
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China.
AD  - Graduate College, Beijing University of Chinese Medicine, Beijing, China.
FAU - Miao, Runyu
AU  - Miao R
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China.
AD  - Graduate College, Beijing University of Chinese Medicine, Beijing, China.
FAU - Yin, Ruiyang
AU  - Yin R
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China.
FAU - Tong, Xiaolin
AU  - Tong X
AD  - Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, 100053, China. tongxiaolin@vip.163.com.
LA  - eng
GR  - 81904187/National Outstanding Youth Science Fund Project of National Natural 
      Science Foundation of China/
GR  - CD2020-4-4155/Capital Health Development Research Special Youth Talent Project/
GR  - ZZ13-YQ-026/China Academy of Traditional Chinese Medicine Outstanding Youth 
      Technology Talent Training Special Project/
GR  - CI2021A01601/Scientific and Technological Innovation Project of China Academy of 
      Chinese Medical Sciences/
GR  - TMSK-2021-407/Translational Medicine National Major Scientific and Technological 
      Infrastructure (Shanghai) Open Topic Project/
PT  - Journal Article
PT  - Review
DEP - 20240304
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Secondary Prevention
MH  - *Coronary Artery Disease
PMC - PMC10910816
OTO - NOTNLM
OT  - Experimental techniques and methodologies
OT  - Macrovascular complications
OT  - Protective mechanisms
OT  - Secondary prevention
OT  - Type 2 diabetes mellitus (T2DM)
COIS- None of the authors have any competing interests.
EDAT- 2024/03/05 00:45
MHDA- 2024/03/06 06:44
PMCR- 2024/03/04
CRDT- 2024/03/04 23:46
PHST- 2023/12/04 00:00 [received]
PHST- 2024/02/21 00:00 [accepted]
PHST- 2024/03/06 06:44 [medline]
PHST- 2024/03/05 00:45 [pubmed]
PHST- 2024/03/04 23:46 [entrez]
PHST- 2024/03/04 00:00 [pmc-release]
AID - 10.1186/s40001-024-01739-1 [pii]
AID - 1739 [pii]
AID - 10.1186/s40001-024-01739-1 [doi]
PST - epublish
SO  - Eur J Med Res. 2024 Mar 4;29(1):152. doi: 10.1186/s40001-024-01739-1.