PMID- 38441748
OWN - NLM
STAT- MEDLINE
DCOM- 20240306
LR  - 20240426
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 36
IP  - 1
DP  - 2024 Mar 5
TI  - Towards a core outcome set (COS) for intrinsic capacity (IC) intervention studies 
      in adults in midlife and beyond: a scoping review to identify frequently used 
      outcomes and measurement tools.
PG  - 54
LID - 10.1007/s40520-023-02681-8 [doi]
LID - 54
AB  - This scoping review was conducted to identify the outcomes and measurement tools 
      used in IC intervention studies, as first step towards the development of a core 
      outcome set (COS) for IC trials. PRISMA-ScR and COS-STAD were followed. The 
      review considered randomized controlled trials targeting IC published in Medline, 
      Scopus, Embase, Cochrane Central Register of Controlled Trials, and 
      clinicaltrials.gov, until June 2023. Of 699 references, 534 studies were screened 
      once duplicates were removed, 15 were assessed for eligibility, and 7 (4 articles 
      and 3 protocols) met eligibility criteria. Twenty-eight outcomes were identified 
      (19 related to IC and its domains and 9 unrelated). The most reported primary 
      outcome was the change in IC levels postintervention (5 over 7 studies) and the 
      most reported outcomes (either as primary and/or secondary) were the changes in 
      physical performance and in depressive symptoms (6 over 7 studies). Fifty-five 
      tools used to construct the domains' z-scores and/or assess the effect of 
      interventions were identified (47 related to IC and its domains and 8 unrelated). 
      The most reported tool was an IC Z-score, calculated by 4 domains' z-scores: 
      locomotor, vitality, cognitive, and psychological (5 over 7 studies). The tools 
      differed among studies (10 locomotor related, 6 vitality related, 16 cognitive 
      related, 8 psychological related, 6 sensorial related, 8 unrelated tools). The 
      vast heterogeneity (28 outcomes and 55 tools within 7 studies) highlighted the 
      need of a COS. These outcomes and tools will be presented to experts in a future 
      step, to select the ones that should be taken into consideration in IC trials.
CI  - (c) 2024. The Author(s).
FAU - Sanchez-Rodriguez, Dolores
AU  - Sanchez-Rodriguez D
AD  - Geriatrics Department, Brugmann University Hospital, Universite Libre de 
      Bruxelles, Brussels, Belgium. DoloresMaria.SANCHEZ-RODRIGUEZ@chu-brugmann.be.
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium. DoloresMaria.SANCHEZ-RODRIGUEZ@chu-brugmann.be.
AD  - Geriatrics Department, Rehabilitation Research Group, Hospital Del Mar Research 
      Institute, Barcelona, Spain. DoloresMaria.SANCHEZ-RODRIGUEZ@chu-brugmann.be.
FAU - Bruyere, Olivier
AU  - Bruyere O
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium.
FAU - Surquin, Murielle
AU  - Surquin M
AD  - Geriatrics Department, Brugmann University Hospital, Universite Libre de 
      Bruxelles, Brussels, Belgium.
FAU - Reginster, Jean-Yves
AU  - Reginster JY
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium.
FAU - Beaudart, Charlotte
AU  - Beaudart C
AD  - WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and 
      Ageing, Division of Public Health, Epidemiology and Health Economics, University 
      of Liege, Liege, Belgium.
AD  - Clinical Pharmacology and Toxicology Research Unit, Faculty of Medicine, NAmur 
      Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, 
      Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20240305
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - Humans
MH  - *Physical Functional Performance
MH  - *Outcome Assessment, Health Care
PMC - PMC10914863
OTO - NOTNLM
OT  - Core outcome set
OT  - ICOPE
OT  - Intrinsic capacity
OT  - Older people
OT  - Scoping review
COIS- DS-R, OB, Y-IR, and CB serve as Senior Advisors to the World Health Organization 
      (WHO) Collaborating Center for Epidemiology of Musculoskeletal Health and Aging, 
      Division of Public Health, Epidemiology, and Health Economics, University of 
      Liege, Liege, Belgium. Y-IR serves as a member of the Board of Directors of the 
      Clinical Consortium on Healthy Ageing (CCHA) of the WHO, Geneva, Switzerland. All 
      authors declare they do not have any personal or financial relationships with 
      other organizations or people that could inappropriately influence their work.
EDAT- 2024/03/05 12:47
MHDA- 2024/03/06 06:43
PMCR- 2024/03/05
CRDT- 2024/03/05 11:22
PHST- 2023/11/03 00:00 [received]
PHST- 2023/11/27 00:00 [accepted]
PHST- 2024/03/06 06:43 [medline]
PHST- 2024/03/05 12:47 [pubmed]
PHST- 2024/03/05 11:22 [entrez]
PHST- 2024/03/05 00:00 [pmc-release]
AID - 10.1007/s40520-023-02681-8 [pii]
AID - 2681 [pii]
AID - 10.1007/s40520-023-02681-8 [doi]
PST - epublish
SO  - Aging Clin Exp Res. 2024 Mar 5;36(1):54. doi: 10.1007/s40520-023-02681-8.