PMID- 38444374
OWN - NLM
STAT- Publisher
LR  - 20240306
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Linking)
DP  - 2024 Mar 6
TI  - Lipoaspirate Injection in Relapsing Idiopathic Subglottic Stenosis: Preliminary 
      Results.
PG  - 34894241237021
LID - 10.1177/00034894241237021 [doi]
AB  - OBJECTIVES: The management of idiopathic subglottic stenosis (iSGS) poses a 
      clinical challenge due to high recurrence rates following both endoscopic and 
      open approaches, often leading to tracheostomy. The activation of abnormal 
      T-cells and cytokine pathways has been linked to iSGS pathogenesis. Autologous 
      adipose tissue centrifugation yields lipoaspirate, offering optimal 
      anti-inflammatory effects and biocompatibility widely utilized in various medical 
      settings. This report presents the first 3 cases employing endoscopic dilation 
      (ED) in combination with local lipoaspirate injection to address recurrent iSGS. 
      METHODS: A prospective observational study was conducted, involving 
      multidisciplinary evaluation by the Tracheal Team at the University of Modena. 
      Patients meeting specific criteria were directed to undergo ED + lipoaspirate 
      injection. RESULTS: Three patients fulfilled the inclusion criteria. The mean 
      number of prior endoscopic procedures performed was 8. Endoscopic examination 
      revealed 90% stenosis in patient A, 60% stenosis in patient B, and 60% stenosis 
      in patient C. All patients presented inflammatory tissue or incipient 
      granulations at the stenotic site, with an average time of 6 months between 
      previous procedures. After 15 months, none of the patients required further 
      procedures, and endoscopic examination revealed a significant reduction or 
      disappearance of inflammatory tissue with a stable airway lumen. CONCLUSIONS: The 
      observed results are encouraging in terms of reducing local inflammation and 
      halting stenosis progression, especially in cases of short-term relapsing iSGS.
FAU - Mattioli, Francesco
AU  - Mattioli F
AD  - Department of Otolaryngology Head and Neck Surgery, University Hospital of 
      Modena, Modena, Italy.
FAU - Serafini, Edoardo
AU  - Serafini E
AUID- ORCID: 0000-0002-4519-1299
AD  - Department of Otolaryngology Head and Neck Surgery, University Hospital of 
      Modena, Modena, Italy.
FAU - Andreani, Alessandro
AU  - Andreani A
AD  - University Hospital of Modena, Respiratory Diseases Unit, Department of Medical 
      and Surgical Sciences, University of Modena Reggio Emilia, Modena, Italy.
FAU - Cappiello, Gaia
AU  - Cappiello G
AD  - University Hospital of Modena, Respiratory Diseases Unit, Department of Medical 
      and Surgical Sciences, University of Modena Reggio Emilia, Modena, Italy.
FAU - De Maria, Federico
AU  - De Maria F
AD  - Department of Medical and Surgical Sciences, Division of Plastic Surgery, 
      University of Modena and Reggio Emilia, Policlinico of Modena, Modena, Italy.
FAU - Marchioni, Daniele
AU  - Marchioni D
AD  - Department of Otolaryngology Head and Neck Surgery, University Hospital of 
      Modena, Modena, Italy.
FAU - Pinelli, Massimo
AU  - Pinelli M
AD  - Department of Medical and Surgical Sciences, Division of Plastic Surgery, 
      University of Modena and Reggio Emilia, Policlinico of Modena, Modena, Italy.
FAU - Marchioni, Alessandro
AU  - Marchioni A
AD  - University Hospital of Modena, Respiratory Diseases Unit, Department of Medical 
      and Surgical Sciences, University of Modena Reggio Emilia, Modena, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240306
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
SB  - IM
OTO - NOTNLM
OT  - endoscopy
OT  - immunology
OT  - subglottic stenosis
OT  - trachea
OT  - tracheo/bronchomalacia
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/03/06 06:43
MHDA- 2024/03/06 06:43
CRDT- 2024/03/06 03:35
PHST- 2024/03/06 06:43 [medline]
PHST- 2024/03/06 06:43 [pubmed]
PHST- 2024/03/06 03:35 [entrez]
AID - 10.1177/00034894241237021 [doi]
PST - aheadofprint
SO  - Ann Otol Rhinol Laryngol. 2024 Mar 6:34894241237021. doi: 
      10.1177/00034894241237021.