PMID- 38444422
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240307
IS  - 1941-2789 (Print)
IS  - 2689-9175 (Electronic)
IS  - 1941-2789 (Linking)
VI  - 17
IP  - 2
DP  - 2024 Feb
TI  - A Multi-center Trial Evaluating a Serum Comprised of Plant-based Adaptogens 
      Targeting Skin Quality.
PG  - 15-19
AB  - OBJECTIVE: The ability of the skin to maintain homeostasis declines with age. 
      Adaptogens support the capacity of the skin to respond to stress. We sought to 
      evaluate the efficacy of a novel serum comprised of plant-based adaptogens for 
      improving photoaged skin following twice-daily application. METHODS: A 
      multi-center, 12-week trial was conducted in participants aged 45 to 65 years, 
      Fitzpatrick Skin Type (FST) I to VI, with mild-to-severe photoaging based on a 
      10-point grading scale (3 [Minimum] to 7 [Maximum]). Visible improvements were 
      assessed in erythema, pore size, skin dullness, skin texture, and uneven 
      pigmentation utilizing a six-point grading scale (0=None to 5=Severe). Global 
      skin quality was measured utilizing our Global Skin Quality Index (GSQI). Sebum 
      measurements were obtained in a subset of participants. Patient satisfaction and 
      tolerability were recorded throughout the study. RESULTS: Fifty-three 
      participants were enrolled and completed the study. Mean age was 56 years and 66 
      percent were White, 17 percent were Black, 8 percent were Hispanic, 6 percent 
      were Asian/Pacific Islander, and 81 percent had moderate photodamage. At Week 12, 
      significant mean percent improvements from baseline were demonstrated in erythema 
      (50%), dullness (44%), texture (52%), pore size (23%), and uneven pigmentation 
      (21%; all p<.0001). Significant GSQI improvements from baseline were observed at 
      Week 12 (39%; p<0.0001). Significant mean reductions from baseline in skin 
      surface sebum were demonstrated at Week 12 (-38%; p<0.0001). All adverse events 
      (AEs) were mild and transient. CONCLUSION: A novel serum comprised of plant-based 
      adaptogens, demonstrated improvements from baseline in the appearance of 
      erythema, dullness, texture, pore size, uneven pigmentation, and global skin 
      quality over 12 weeks. Participants reported high levels of satisfaction, with 
      mild, transient AEs reported.
CI  - Copyright (c) 2024. Matrix Medical Communications. All rights reserved.
FAU - Draelos, Zoe Diana
AU  - Draelos ZD
AD  - Dr. Draelos is with Dermatology Consulting Services PLLC in High Point, North 
      Carolina.
FAU - Grimes, Pearl E
AU  - Grimes PE
AD  - Dr. Grimes is with The Grimes Center of Medical and Aesthetic Dermatology and the 
      Vitiligo and Pigmentation Institute of Southern California in Los Angeles, 
      California.
FAU - Watchmaker, Jacqueline
AU  - Watchmaker J
AD  - Dr. Watchmaker is with Southwest Skin Specialists in Scottsdale, Arizona.
FAU - Nelson, Diane B
AU  - Nelson DB
AD  - Ms. Nelson is with Skinbetter Science, a Dermatological Beauty brand of L'Oreal 
      USA, Inc., in Phoenix, Arizona.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Aesthet Dermatol
JT  - The Journal of clinical and aesthetic dermatology
JID - 101518173
PMC - PMC10911267
OTO - NOTNLM
OT  - Plants
OT  - adaptogens
OT  - cosmeceuticals
OT  - homeostasis
OT  - photoaging
OT  - photodamage
OT  - skin quality
COIS- DISCLOSURES.: Drs. Draelos, Grimes and Watchmaker were investigators on this 
      study; Diane Nelson is an employee of skinbetter science.
EDAT- 2024/03/06 06:43
MHDA- 2024/03/06 06:44
PMCR- 2024/02/01
CRDT- 2024/03/06 03:47
PHST- 2024/03/06 06:44 [medline]
PHST- 2024/03/06 06:43 [pubmed]
PHST- 2024/03/06 03:47 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
PST - ppublish
SO  - J Clin Aesthet Dermatol. 2024 Feb;17(2):15-19.