PMID- 38444507
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240307
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 5
DP  - 2024 Mar 15
TI  - Microbiota substances modulate dendritic cells activity: A critical view.
PG  - e27125
LID - 10.1016/j.heliyon.2024.e27125 [doi]
LID - e27125
AB  - Contemporary research in the field of microbiota shows that commensal bacteria 
      influence physiological activity of different organs and systems of a human 
      organism, such as brain, lungs, immune and metabolic systems. This influence is 
      realized by various processes. One of them is trough modulation of immune 
      mechanisms. Interactions between microbiota and the human immune system are known 
      to be complex and ambiguous. Dendritic cells (DCs) are unique cells, which 
      initiate the development and polarization of adaptive immune response. These 
      cells also interconnect native and specific immune reactivity. A large set of 
      biochemical signals from microbiota in the form of different microbiota 
      associated molecular patterns (MAMPs) and bacterial metabolites that act locally 
      and distantly in the human organism. As a result, commensal bacteria influence 
      the maturity and activity of dendritic cells and affect the overall immune 
      reactivity of the human organism. It then determines the response to pathogenic 
      microorganisms, inflammation, associated with different pathological conditions 
      and even affects the effectiveness of vaccination.
CI  - (c) 2024 The Authors.
FAU - Shvets, Yuliia
AU  - Shvets Y
AD  - Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 
      Ukraine.
FAU - Khranovska, Natalia
AU  - Khranovska N
AD  - National Cancer Institute of Ukraine, 33/43 Yuliia Zdanovska Str., Kyiv, Ukraine.
FAU - Senchylo, Natalia
AU  - Senchylo N
AD  - Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 
      Ukraine.
FAU - Ostapchenko, Danylo
AU  - Ostapchenko D
AD  - Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 
      Ukraine.
FAU - Tymoshenko, Iryna
AU  - Tymoshenko I
AD  - Bogomolets National Medical University, 13 Shevchenka Blvd., Kyiv, Ukraine.
FAU - Onysenko, Svitlana
AU  - Onysenko S
AD  - Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 
      Ukraine.
FAU - Kobyliak, Nazarii
AU  - Kobyliak N
AD  - Bogomolets National Medical University, 13 Shevchenka Blvd., Kyiv, Ukraine.
AD  - Medical Laboratory CSD, 22b Zhmerynska Str., Kyiv, Ukraine.
FAU - Falalyeyeva, Tetyana
AU  - Falalyeyeva T
AD  - Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 
      Ukraine.
AD  - Medical Laboratory CSD, 22b Zhmerynska Str., Kyiv, Ukraine.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240225
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10912702
OTO - NOTNLM
OT  - Antigen presenting cells
OT  - Autoinducer
OT  - Commensal bacteria
OT  - Lipopolysaccharide
OT  - Peptidoglycan
OT  - Secondary bile acid
OT  - Short chain fatty acid
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/03/06 06:43
MHDA- 2024/03/06 06:44
PMCR- 2024/02/25
CRDT- 2024/03/06 03:47
PHST- 2023/11/21 00:00 [received]
PHST- 2024/02/23 00:00 [revised]
PHST- 2024/02/23 00:00 [accepted]
PHST- 2024/03/06 06:44 [medline]
PHST- 2024/03/06 06:43 [pubmed]
PHST- 2024/03/06 03:47 [entrez]
PHST- 2024/02/25 00:00 [pmc-release]
AID - S2405-8440(24)03156-6 [pii]
AID - e27125 [pii]
AID - 10.1016/j.heliyon.2024.e27125 [doi]
PST - epublish
SO  - Heliyon. 2024 Feb 25;10(5):e27125. doi: 10.1016/j.heliyon.2024.e27125. 
      eCollection 2024 Mar 15.