PMID- 38444566
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240307
IS  - 1179-9900 (Electronic)
IS  - 1179-9900 (Linking)
VI  - 14
DP  - 2024
TI  - Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A 
      Case Report.
PG  - 15-19
LID - 10.2147/DNND.S451611 [doi]
AB  - Myasthenia gravis (MG) is an autoimmune disease which can impact pregnancy. We 
      describe a transient neonatal myasthenia gravis (TNMG) born to an asymptomatic 
      mother aged 26. The newborn presented cyanosis and generalized muscular weakness 
      quickly after birth. Nasal continuous positive airway pressure (nCPAP) 
      ventilation was performed immediately. On day 3, detailed family history showed 
      that the neonate's 50-year-old maternal grandmother was diagnosed as ocular MG at 
      the age of 40. Ryanodine receptor calcium release channel antibody (RyR-Ab) and 
      acetylcholine receptor antibody (AChR-Ab) tested on day 5 were positive. However, 
      neostigmine tests were negative for the neonate. Intravenous immunoglobulin 
      (IVIG) and oral pyridostigmine were administered. The infant was weaned from the 
      ventilator on day 7. On day 10, the neonate's asymptomatic mother was confirmed 
      to have positive AChR-Ab either. The neonate regained the capability of bottle 
      feeding on day 17 and discharged on day 26. Asymptomatic pregnant women with MG 
      family history can also deliver infants who develop TNMG. Testing AChR antibodies 
      in pregnant women with a family history of MG should be necessary as TNMG was a 
      life-threatening disease. With timely diagnosis and accurate treatment, TNMG can 
      be effectively relieved.
CI  - (c) 2024 Yang et al.
FAU - Yang, Jinrong
AU  - Yang J
AD  - Department of Neonatology, Shenzhen Third People's Hospital, The Second 
      Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 
      Guangdong, People's Republic of China.
FAU - Pan, Liping
AU  - Pan L
AD  - Department of Neonatology, Shenzhen Third People's Hospital, The Second 
      Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 
      Guangdong, People's Republic of China.
FAU - Liu, Yaping
AU  - Liu Y
AD  - Department of Neonatology, Shenzhen Third People's Hospital, The Second 
      Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 
      Guangdong, People's Republic of China.
FAU - Wang, Yanrong
AU  - Wang Y
AD  - Department of Neonatology, Shenzhen Third People's Hospital, The Second 
      Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 
      Guangdong, People's Republic of China.
LA  - eng
PT  - Case Reports
DEP - 20240301
PL  - New Zealand
TA  - Degener Neurol Neuromuscul Dis
JT  - Degenerative neurological and neuromuscular disease
JID - 101587980
PMC - PMC10913793
OTO - NOTNLM
OT  - IVIG
OT  - asymptomatic MG
OT  - pyridostigmine
OT  - transient neonatal myasthenia gravis
COIS- None of the authors has any conflict of interest to disclose for this work.
EDAT- 2024/03/06 06:43
MHDA- 2024/03/06 06:44
PMCR- 2024/03/01
CRDT- 2024/03/06 03:49
PHST- 2023/12/05 00:00 [received]
PHST- 2024/02/26 00:00 [accepted]
PHST- 2024/03/06 06:44 [medline]
PHST- 2024/03/06 06:43 [pubmed]
PHST- 2024/03/06 03:49 [entrez]
PHST- 2024/03/01 00:00 [pmc-release]
AID - 451611 [pii]
AID - 10.2147/DNND.S451611 [doi]
PST - epublish
SO  - Degener Neurol Neuromuscul Dis. 2024 Mar 1;14:15-19. doi: 10.2147/DNND.S451611. 
      eCollection 2024.