PMID- 38447517 OWN - NLM STAT- MEDLINE DCOM- 20240318 LR - 20240318 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 273 DP - 2024 Mar 15 TI - Associations between maternal serum neonicotinoid pesticide exposure during pregnancy and newborn telomere length: Effect modification by sampling season. PG - 116164 LID - S0147-6513(24)00239-2 [pii] LID - 10.1016/j.ecoenv.2024.116164 [doi] AB - BACKGROUND: An increasing amount of evidence suggests that telomere length (TL) at birth can predict lifespan and is associated with chronic diseases later in life, but newborn TL may be affected by environmental pollutants. Neonicotinoids (NEOs) are widely used worldwide, and despite an increasing number of studies showing that they may have adverse effects on birth in mammals and even humans, few studies have examined the effect of NEO exposure on newborn TLs. OBJECTIVE: To investigate the effects of prenatal exposure to NEOs and the interactions between NEOs and sampling season on newborn TL. METHODS: We conducted a prospective cohort study of 500 mother-newborn pairs from the Guangxi Zhuang Birth Cohort. Ultraperformance liquid chromatographymass spectrometry was used to detect ten NEOs in maternal serum, and fluorescence quantitative PCR was used to estimate the newborn TL. A generalized linear model (GLM) was used to evaluate the relationships between individual NEO exposures and TLs , and quantile g-computation (Qgcomp) model and Bayesian kernel machine regression (BKMR) model were used to evaluate the combined effect of mixtures of components. RESULTS: The results of the GLM showed that compared with maternal TMX levels < LOD, maternal TMX levels < median were negatively correlated with newborn TL (-6.93%, 95% CI%: -11.92%, -1.66%), and the decrease in newborn TL was more pronounced in girls (-9.60%, 95% CI: -16.84%, -1.72%). Moreover, different kinds of maternal NEO exposure had different effects on newborn TL in different sampling seasons, and the effect was statistically significant in all seasons except in autumn. Mixed exposure analysis revealed a potential positive trend between NEOs and newborn TL, but the association was not statistically significant. CONCLUSION: Prenatal exposure to TMX may shorten newborn TL, and this effect is more pronounced among female newborns. Furthermore, the relationship between NEO exposure and TL may be modified by the sampling season. CI - Copyright (c) 2024. Published by Elsevier Inc. FAU - Mu, Changhui AU - Mu C AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Lin, Mengrui AU - Lin M AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Shao, Yantao AU - Shao Y AD - Department of Medical and Health Management, Logistics Infrastructure Department, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Liao, Qian AU - Liao Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Liang, Jun AU - Liang J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Yu, Chuanxiang AU - Yu C AD - Wujiang District Center for Disease Control and Prevention, Suzhou 215299, China. FAU - Wu, Xiaolin AU - Wu X AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Chen, Manlin AU - Chen M AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Tang, Ying AU - Tang Y AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Zhou, Lihong AU - Zhou L AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Qiu, Xiaoqiang AU - Qiu X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: xqqiu9999@163.com. FAU - Pan, Dongxiang AU - Pan D AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: gxpandongxiang@163.com. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: dongpinghuang@gxmu.edu.cn. LA - eng PT - Journal Article DEP - 20240305 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 SB - IM MH - Pregnancy MH - Humans MH - Infant, Newborn MH - Female MH - *Prenatal Exposure Delayed Effects/genetics MH - Seasons MH - Prospective Studies MH - Bayes Theorem MH - Cohort Studies MH - China MH - Maternal Exposure/adverse effects MH - Telomere OTO - NOTNLM OT - Maternal exposure OT - Neonicotinoid pesticides OT - Newborns OT - Sampling season OT - Telomere length COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/07 00:42 MHDA- 2024/03/18 06:44 CRDT- 2024/03/06 18:14 PHST- 2023/08/05 00:00 [received] PHST- 2024/02/24 00:00 [revised] PHST- 2024/02/27 00:00 [accepted] PHST- 2024/03/18 06:44 [medline] PHST- 2024/03/07 00:42 [pubmed] PHST- 2024/03/06 18:14 [entrez] AID - S0147-6513(24)00239-2 [pii] AID - 10.1016/j.ecoenv.2024.116164 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2024 Mar 15;273:116164. doi: 10.1016/j.ecoenv.2024.116164. Epub 2024 Mar 5.