PMID- 38447761
OWN - NLM
STAT- Publisher
LR  - 20240306
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
DP  - 2024 Mar 4
TI  - Pro-inflammatory markers are related to cortical network connectivity in women 
      exposed to interpersonal trauma with PTSD.
PG  - 114942
LID - S0166-4328(24)00098-6 [pii]
LID - 10.1016/j.bbr.2024.114942 [doi]
AB  - Exposure to interpersonal violence affects a significant number of individuals 
      each year and further increases the risk for developing Posttraumatic Stress 
      Disorder (PTSD). A growing body of research suggests that immune system 
      dysfunction, in particular elevated inflammation, may contribute to the 
      pathophysiology of PTSD. However, few studies have examined the neurobiological 
      correlates of inflammation in women with PTSD using resting-state fMRI. The 
      present study explored the relationship between pro-inflammatory cytokine levels, 
      C-reactive protein (CRP), tumor necrosis factor alpha TNF-alpha), and 
      interleukin-6 (IL-6), and resting-state functional connectivity patterns in three 
      major cortical networks (default mode network (DMN), central executive network 
      (CEN), and salience network (SN)) in a sample of women (N=18) exposed to 
      interpersonal violence with PTSD. Results indicated that higher CRP levels were 
      associated with stronger functional connectivity between the SN and visual areas, 
      but weaker functional connectivity between the CEN and visual areas. These 
      findings suggest that pro-inflammatory markers are related to connectivity of 
      task-positive networks in women with PTSD. Further, our results provide evidence 
      for potential neurobiological markers of inflammation in PTSD.
CI  - Copyright (c) 2024. Published by Elsevier B.V.
FAU - Yetter, Marissa A
AU  - Yetter MA
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, Missouri, 63121, USA; University of Missouri - St. 
      Louis.
FAU - Fitzgerald, Taryn R
AU  - Fitzgerald TR
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, Missouri, 63121, USA; University of Missouri - St. 
      Louis.
FAU - Philippi, Carissa L
AU  - Philippi CL
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, Missouri, 63121, USA; University of Missouri - St. 
      Louis.
FAU - Bruce, Steven E
AU  - Bruce SE
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, Missouri, 63121, USA; University of Missouri - St. 
      Louis.
LA  - eng
PT  - Journal Article
DEP - 20240304
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
OTO - NOTNLM
OT  - C-reactive protein
OT  - PTSD
OT  - inflammation
OT  - interpersonal trauma
OT  - posttraumatic stress disorder
OT  - resting-state functional connectivity
EDAT- 2024/03/07 00:42
MHDA- 2024/03/07 00:42
CRDT- 2024/03/06 19:16
PHST- 2024/02/29 00:00 [received]
PHST- 2024/03/03 00:00 [accepted]
PHST- 2024/03/07 00:42 [medline]
PHST- 2024/03/07 00:42 [pubmed]
PHST- 2024/03/06 19:16 [entrez]
AID - S0166-4328(24)00098-6 [pii]
AID - 10.1016/j.bbr.2024.114942 [doi]
PST - aheadofprint
SO  - Behav Brain Res. 2024 Mar 4:114942. doi: 10.1016/j.bbr.2024.114942.